癌症患者中的隐匿性肺栓塞。

Unsuspected pulmonary embolism in patients with cancer.

机构信息

Department of Internal Medicine, Hospital Sant Jaume, Olot, Gerona, Spain.

出版信息

Thromb Res. 2012 Apr;129 Suppl 1:S16-9. doi: 10.1016/S0049-3848(12)70010-5.

DOI:10.1016/S0049-3848(12)70010-5

PMID:22682127

Abstract

BACKGROUND

The natural history of unsuspected pulmonary embolism (PE) in patients with cancer has not been thoroughly studied.

METHODS

We used the RIETE Registry data to compare the clinical characteristics, treatment strategies and outcome in cancer patients with unsuspected PE and in those presenting with symptomatic, acute PE.

RESULTS

Up to December 2011, 78 cancer patients with unsuspected PE and 1,994 with symptomatic PE had been enrolled. Patients with unsuspected PE more likely had colorectal cancer than those with symptomatic PE (28% vs. 13%), and less likely had prostate (3.8% vs. 10%) or hematologic (1.3% vs. 6.4%) cancer, or prior venous thromboembolism (3.8% vs. 12%). While the patients were receiving anticoagulant therapy, the incidence of PE recurrences (0% vs. 1.9%) or major bleeding (2.6% vs. 4.8%) were similar. After completion of anticoagulation, recurrent PE developed in 2.6% vs. 1.4% of patients, and major bleeding in 0% vs. 0.4%, respectively.

CONCLUSIONS

Our findings suggest that the clinical characteristics and outcome in cancer patients with unsuspected PE are quite similar to those in patients with symptomatic PE.

摘要

背景

尚未确诊的癌症患者肺栓塞（PE）的自然病史尚未得到充分研究。

方法

我们使用 RIETE 登记数据，比较了无症状 PE 和有症状、急性 PE 的癌症患者的临床特征、治疗策略和结局。

结果

截至 2011 年 12 月，登记了 78 例无症状 PE 癌症患者和 1994 例有症状 PE 癌症患者。与有症状 PE 患者相比，无症状 PE 患者更可能患有结直肠癌（28% vs. 13%），而不太可能患有前列腺癌（3.8% vs. 10%）或血液系统癌症（1.3% vs. 6.4%）或既往静脉血栓栓塞症（3.8% vs. 12%）。在接受抗凝治疗期间，PE 复发（0% vs. 1.9%）或大出血（2.6% vs. 4.8%）的发生率相似。抗凝治疗完成后，分别有 2.6%和 1.4%的患者出现复发性 PE，0%和 0.4%的患者出现大出血。