Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Thromb Res. 2012 Apr;129 Suppl 1:S69-75. doi: 10.1016/S0049-3848(12)70020-8.
Tissue factor (TF), the trigger of blood coagulation, is a 47 kDa membrane protein that also impacts on non-hemostatic processes, such as atherosclerosis, primary tumor growth and metastasis. TF binding to its ligand FVIIa induces activation of protease-activated receptor-2 and this event is thought to considerably influence atherosclerosis and tumor angiogenesis. TF-dependent activation of the coagulation cascade, rather than PAR-2 activation, then leads to the potentiation of metastasis. Importantly, a soluble alternatively spliced isoform of TF (asTF) has been discovered, but the function of asTF in hemostatic and non-hemostatic events is poorly understood. In this review, we aim to present a side-by-side evaluation of normally-spliced, full length TF (flTF) and asTF with regard to coagulant function, atherosclerosis, tumor progression and malignancy-associated thrombosis.
组织因子（TF），即凝血的触发因子，是一种 47kDa 的膜蛋白，也会影响非止血过程，如动脉粥样硬化、原发性肿瘤生长和转移。TF 与其配体 FVIIa 结合可诱导蛋白酶激活受体-2 的激活，据认为这一事件对动脉粥样硬化和肿瘤血管生成有很大影响。凝血级联的 TF 依赖性激活，而不是 PAR-2 的激活，进而导致转移的增强。重要的是，已经发现了 TF 的一种可溶性剪接异构体（asTF），但 asTF 在止血和非止血事件中的功能尚不清楚。在这篇综述中，我们旨在对正常剪接的全长 TF（flTF）和 asTF 就其凝血功能、动脉粥样硬化、肿瘤进展和与恶性肿瘤相关的血栓形成进行并排评估。
