Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Thromb Res. 2012 Apr;129 Suppl 1:S88-92. doi: 10.1016/S0049-3848(12)70024-5.
Patients diagnosed with multiple myeloma have an increased risk of venous thrombosis. This may be due to various risk factors, including disease specific factors, changes in coagulation and fibrinolysis factors and circulating prothrombotic microparticles. More recent studies have indicated that also arterial thrombosis, including acute myocardial infarction and stroke do occur more frequently in these patients. Studies on etiological factors contributing to the development of thrombosis will be reviewed in this article. In addition we will focus on the prevention and management of arterial and venous thrombosis in patients with multiple myeloma.
患有多发性骨髓瘤的患者发生静脉血栓的风险增加。这可能是由于多种危险因素所致，包括疾病特异性因素、凝血和纤溶因子变化以及循环促血栓形成的微粒。最近的研究表明，这些患者也更常发生动脉血栓形成，包括急性心肌梗死和中风。本文将回顾导致血栓形成的病因学因素的研究。此外，我们将重点关注多发性骨髓瘤患者的动脉和静脉血栓形成的预防和管理。
