Mycology Section, Department of Dermatology, Dr. Manuel Gea Gonzalez General Hospital, Calzada de Tlalpan 4800, Colonia Sección XVI, Mexico, DF, Mexico.
Clin Dermatol. 2012 Jul-Aug;30(4):437-43. doi: 10.1016/j.clindermatol.2011.09.017.
Sporotrichosis is the most common subcutaneous mycosis. It is usually acquired by traumatic inoculation, and it is caused by one of the species of the Sporothrix schenckii complex. More than 6 species, such as S schenckii sensu stricto, Sporothrix brasiliensis, Sporothrix globosa, Sporothrix mexicana, and Sporothrix albicans, have been identified by molecular techniques. The most common presentation is cutaneous disease, which is classified into fixed and lymphocutaneous forms. Osteoarticular, pulmonary, mucosal, disseminated, and systemic infections are less common and usually occur in immunosuppressed individuals. The diagnosis is suggested by biopsy specimen and confirmed by tissue culture. Itraconazole is considered the treatment of choice, although in some undeveloped countries potassium iodide is still used, owing to its safety and low cost. For systemic or disseminated cases, amphotericin B is the treatment of choice.
孢子丝菌病是最常见的皮下真菌病。它通常通过创伤接种获得,由申克孢子丝菌复合体的一种物种引起。通过分子技术已经鉴定出超过 6 个种,如 S schenckii sensu stricto、Sporothrix brasiliensis、Sporothrix globosa、Sporothrix mexicana 和 Sporothrix albicans。最常见的表现是皮肤疾病,分为固定性和淋巴管性两种形式。骨关节炎、肺部、黏膜、播散性和全身性感染较少见,且通常发生在免疫抑制个体中。通过活检标本提示诊断,并通过组织培养确认。伊曲康唑被认为是治疗的首选药物,尽管在一些欠发达国家,由于其安全性和低成本,碘化钾仍在使用。对于系统性或播散性病例,两性霉素 B 是首选治疗药物。