Wnt/β-连环蛋白信号通路与疾病

Wnt/β-catenin signaling and disease.

机构信息

Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands.

出版信息

Cell. 2012 Jun 8;149(6):1192-205. doi: 10.1016/j.cell.2012.05.012.

DOI:10.1016/j.cell.2012.05.012

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

摘要

WNT 信号转导级联在所有动物的发育和成年生活中控制着无数的生物学现象。与此同时，异常的 Wnt 信号是人类多种疾病的基础。在这篇综述中，我们提供了对核心 Wnt/β-连环蛋白信号通路的最新更新，讨论了其各种成分如何导致疾病，并提出了未来需要解决的悬而未决的问题。