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胰岛素样生长因子系统在骨骼中的基础与临床意义。

The insulin-like growth factor system in bone: basic and clinical implications.

机构信息

Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.

出版信息

Endocrinol Metab Clin North Am. 2012 Jun;41(2):323-33, vi. doi: 10.1016/j.ecl.2012.04.013. Epub 2012 May 15.

DOI:10.1016/j.ecl.2012.04.013
PMID:22682633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3576021/
Abstract

The insulin-like growth factor (IGF) regulatory system is critical for skeletal growth and maintenance. Initially there was great hope that the recombinant IGFs might be used clinically for disorders ranging from short stature to fracture repair and osteoporosis. Although this potential was not realized, basic and translational studies have continued, providing significant insights into the role of this family of growth factors in skeletal homeostasis and the pathophysiology of several bone disorders. This article reviews the importance of the IGF regulatory system in skeletal growth and maintenance.

摘要

胰岛素样生长因子（IGF）调节系统对于骨骼生长和维持至关重要。最初人们曾寄予厚望，认为重组 IGF 可能会用于治疗从身材矮小到骨折修复和骨质疏松症等各种疾病。尽管这一潜力尚未实现，但基础和转化研究仍在继续，为该家族生长因子在骨骼内稳态和几种骨骼疾病的病理生理学中的作用提供了重要的见解。本文综述了 IGF 调节系统在骨骼生长和维持中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d06/3576021/ecb536a16940/nihms372205f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d06/3576021/ecb536a16940/nihms372205f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d06/3576021/ecb536a16940/nihms372205f1.jpg

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本文引用的文献

1
Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1.血清 IGF-1 水平升高足以维持正常的体型和骨骼特征，即使在组织 IGF-1 缺乏的情况下也是如此。
J Bone Miner Res. 2010 Jun;25(6):1257-66. doi: 10.1002/jbmr.20.
2
The hormonal action of IGF1 in postnatal mouse growth.胰岛素样生长因子1（IGF1）在出生后小鼠生长中的激素作用。
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.
3
IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts.成骨细胞分泌的胰岛素样生长因子-I（IGF-I）是一种对成骨细胞有效的趋化因子。
Bone. 2008 Nov;43(5):869-79. doi: 10.1016/j.bone.2008.07.241. Epub 2008 Jul 31.
4
Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity).胰岛素样生长因子-I治疗拉伦综合征（原发性生长激素不敏感）儿童。
Pediatr Endocrinol Rev. 2008 Mar;5(3):766-71.
5
Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo.胰岛素样生长因子（IGF）结合蛋白-4在体内既是IGF活性的正向调节因子，也是负向调节因子。
Mol Endocrinol. 2008 May;22(5):1213-25. doi: 10.1210/me.2007-0536. Epub 2008 Feb 7.
6
Lifelong accumulation of bone in mice lacking Pten in osteoblasts.成骨细胞中缺乏Pten的小鼠骨骼的终身积累。
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2259-64. doi: 10.1073/pnas.0604153104. Epub 2007 Feb 7.
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J Clin Endocrinol Metab. 2006 Jun;91(6):2264-71. doi: 10.1210/jc.2005-2146. Epub 2006 Mar 28.
9
Postnatal growth and bone mass in mice with IGF-I haploinsufficiency.IGF-I单倍体不足小鼠的出生后生长和骨量
Bone. 2006 Jun;38(6):826-35. doi: 10.1016/j.bone.2005.11.021. Epub 2006 Jan 19.
10
The insulin-like growth factor-I gene and osteoporosis: a critical appraisal.胰岛素样生长因子-I基因与骨质疏松症：批判性评估
Gene. 2005 Nov 21;361:38-56. doi: 10.1016/j.gene.2005.07.016. Epub 2005 Sep 22.