胰岛素样生长因子系统在骨骼中的基础与临床意义。
The insulin-like growth factor system in bone: basic and clinical implications.
机构信息
Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
出版信息
Endocrinol Metab Clin North Am. 2012 Jun;41(2):323-33, vi. doi: 10.1016/j.ecl.2012.04.013. Epub 2012 May 15.
Abstract
The insulin-like growth factor (IGF) regulatory system is critical for skeletal growth and maintenance. Initially there was great hope that the recombinant IGFs might be used clinically for disorders ranging from short stature to fracture repair and osteoporosis. Although this potential was not realized, basic and translational studies have continued, providing significant insights into the role of this family of growth factors in skeletal homeostasis and the pathophysiology of several bone disorders. This article reviews the importance of the IGF regulatory system in skeletal growth and maintenance.
摘要
胰岛素样生长因子（IGF）调节系统对于骨骼生长和维持至关重要。最初人们曾寄予厚望，认为重组 IGF 可能会用于治疗从身材矮小到骨折修复和骨质疏松症等各种疾病。尽管这一潜力尚未实现，但基础和转化研究仍在继续，为该家族生长因子在骨骼内稳态和几种骨骼疾病的病理生理学中的作用提供了重要的见解。本文综述了 IGF 调节系统在骨骼生长和维持中的重要性。
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