在从静止状态刺激的3T3细胞中，诱导胸苷激酶需要锌离子，但诱导鸟氨酸脱羧酶则不需要。
A requirement for Zn2+ for the induction of thymidine kinase but not ornithine decarboxylase in 3T3 cells stimulated from quiescence.
作者信息
Chesters J K, Petrie L, Travis A J
机构信息
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
出版信息
Biochem J. 1990 Dec 1;272(2):525-7. doi: 10.1042/bj2720525.
Abstract
In 3T3 cells stimulated from quiescence by serum, impaired thymidine incorporation caused by inadequate supply of Zn2+ was associated with both decreased thymidine kinase activity and a comparable decrease in its mRNA concentration. In contrast, the amount of mRNA for ribosomal protein S6 was not affected, nor was the earlier increase in the activity of ornithine decarboxylase.
摘要
在血清刺激下从静止状态激活的3T3细胞中，锌离子供应不足导致的胸苷掺入受损与胸苷激酶活性降低及其mRNA浓度的相应降低有关。相比之下，核糖体蛋白S6的mRNA量未受影响，鸟氨酸脱羧酶活性的早期增加也未受影响。
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