Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8641, Japan.
Cytokine. 2012 Oct;60(1):226-32. doi: 10.1016/j.cyto.2012.05.003. Epub 2012 Jun 8.
To investigate the role of alternative activation of macrophages, in particular, the role of the CD163/HO-1 axis in systemic juvenile idiopathic arthritis (s-JIA), we serially examined the concentrations of HO-1, sCD163 and pro-inflammatory cytokines (IL-10, IL-18, IL-6, neopterin, soluble TNF-α receptor types I and II) in patients with s-JIA complicated by macrophage activation syndrome (MAS/s-JIA). Serum concentrations of HO-1, sCD163 and IL-10 in s-JIA patients were markedly elevated in the active phase including MAS and correlated positively with indicators for s-JIA disease activity. Serum concentrations of HO-1, sCD163 and IL-10, as well as IL-18, remained elevated in s-JIA patients even in the inactive phase of disease, whereas clinical parameters and other pro-inflammatory cytokines normalized. These findings indicate that alternative macrophage activation plays an important role not only in the active phase but also in the inactive phase of s-JIA. These findings suggest that the inactive phase of s-JIA represents a state of compensated inflammation rather than absence of immune activity.
为了研究巨噬细胞的替代激活作用，特别是 CD163/HO-1 轴在全身型幼年特发性关节炎（s-JIA）中的作用，我们连续检测了并发巨噬细胞活化综合征（MAS/s-JIA）的 s-JIA 患者中 HO-1、sCD163 和促炎细胞因子（IL-10、IL-18、IL-6、新蝶呤、可溶性 TNF-α 受体 I 和 II）的浓度。s-JIA 患者在活动期（包括 MAS）中血清 HO-1、sCD163 和 IL-10 浓度明显升高，并与 s-JIA 疾病活动的指标呈正相关。即使在疾病的非活动期，s-JIA 患者的血清 HO-1、sCD163 和 IL-10 以及 IL-18 浓度仍升高，而临床参数和其他促炎细胞因子则恢复正常。这些发现表明，替代的巨噬细胞激活不仅在活动期，而且在 s-JIA 的非活动期也起着重要作用。这些发现表明，s-JIA 的非活动期代表一种代偿性炎症状态，而不是免疫活性缺失。
