Division of Rhinology and Sinus Surgery, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, 53226, USA.
Am J Otolaryngol. 2012 Nov-Dec;33(6):663-6. doi: 10.1016/j.amjoto.2012.04.001. Epub 2012 Jun 7.
Fulminant invasive fungal sinusitis (IFS) is an aggressive disease seen in patients who are severely neutropenic. The use of granulocyte transfusions to address neutropenia-associated IFS has been described for almost 2 decades. The objectives are to provide our experience using granulocyte transfusions in patients with IFS and to provide a current review of the literature.
A retrospective chart review was performed at the Medical College of Wisconsin to identify patients who received granulocyte transfusions for IFS. Data collected included age, original diagnosis, IFS pathogen, dates, transfusion number, reason for discontinuation, additional therapies, last known follow-up, and status at last known follow-up. A Medline search and manual review of citations within bibliographies was also performed.
A total of 20 patients received granulocyte transfusions at the Medical College of Wisconsin between October 2003 and June 2009; 3 of these patients received granulocyte transfusions for fulminant IFS. A total of 22 reported cases of IFS treated with granulocyte transfusions exist in the current literature.
Although limitations to the use of granulocyte transfusions exist, they still represent a viable treatment option in individuals who fail to respond to more conventional therapies.
暴发性侵袭性真菌性鼻窦炎（IFS）是一种严重中性粒细胞减少症患者中出现的侵袭性疾病。近 20 年来，已有描述使用粒细胞输注来解决与中性粒细胞减少相关的 IFS。目的是提供我们在 IFS 患者中使用粒细胞输注的经验，并对文献进行综述。
在威斯康星医学院进行了回顾性图表审查，以确定接受粒细胞输注治疗 IFS 的患者。收集的数据包括年龄、原始诊断、IFS 病原体、日期、输注次数、停药原因、其他治疗方法、最近的已知随访以及最后一次已知随访时的情况。还进行了 Medline 搜索和参考文献内引文的手动审查。
2003 年 10 月至 2009 年 6 月期间，威斯康星医学院共有 20 名患者接受了粒细胞输注；其中 3 名患者因暴发性 IFS 接受了粒细胞输注。目前文献中有 22 例 IFS 患者接受粒细胞输注治疗的报道。
尽管粒细胞输注的使用存在局限性，但对于那些对更常规治疗方法无反应的患者，它们仍然是一种可行的治疗选择。
