Samadi D S, Goldberg A N, Orlandi R R
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, USA.
Am J Rhinol. 2001 Jul-Aug;15(4):263-5.
Usually, fulminant, invasive fungal rhinosinusitis is observed in the immunocompromised patient and is associated with significant morbidty, and mortality. A high index of suspicion and early diagnosis is imperative for optimizing outcome. Mainstays of treatment include antifungal agents and radical resection of necrotic tissue. Reversal of the underlying medical condition, when possible, is a critical part of the management. In the neutropenic population, granulocyte transfusion may represent an adjunct to current therapy. We provide the first report of a case of invasive fungal rhinosinusitis in which this intervention was used.
通常，暴发性侵袭性真菌性鼻-鼻窦炎见于免疫功能低下的患者，且与显著的发病率和死亡率相关。高度怀疑并早期诊断对于优化治疗结果至关重要。治疗的主要方法包括抗真菌药物和坏死组织的根治性切除。尽可能纠正潜在的基础疾病是治疗的关键部分。在中性粒细胞减少的人群中，粒细胞输注可能是当前治疗的一种辅助手段。我们首次报告了一例使用该干预措施的侵袭性真菌性鼻-鼻窦炎病例。
