Clinic of Companion Animal Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 11 Stavrou Voutyra Str, 54627 Thessaloniki, Greece.
Vet Parasitol. 2012 Nov 23;190(1-2):191-5. doi: 10.1016/j.vetpar.2012.05.013. Epub 2012 May 23.
Canine spirocercosis (CS) is a helminthic infection caused by the nematode Spirocerca lupi. The clinical hallmark of the disease is esophageal dysphagia due to parasite-induced esophageal nodules. Currently, there is limited information on the involvement of serum acute phase proteins (APPs) in the symptomatic CS. The objective of this study was to investigate whether C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp) and albumin are involved in CS, and if their concentrations measured on admission reflect the severity of benign esophageal lesions. Nineteen dogs with spontaneous symptomatic esophageal spirocercosis and 7 clinically healthy dogs were studied retrospectively. The most consistently increased APP in the symptomatic dogs was Hp (95% of the dogs), followed by CRP (68%). The SAA concentrations were infrequently increased (5% of the dogs), while albumin concentrations were decreased in 58% of the affected dogs. The dogs with spirocercosis had significantly higher median concentrations of Hp (p=0.0001) and CRP (p=0.02) compared to healthy dogs. Median albumin concentrations did not differ between the two groups of dogs. The median concentrations of Hp, CRP and albumin did not differ significantly between the dogs having a single or multiple esophageal nodules. The results of this study indicate that in symptomatic CS, Hp and CRP are significantly and consistently increased, while SAA and albumin may be of limited value as diagnostic markers. No association was established between the concentrations of Hp, CRP and albumin measured on admission and the number of esophageal nodules.
犬旋毛虫病（CS）是由旋毛线虫引起的寄生虫感染。该病的临床特征是寄生虫引起的食管结节导致食管吞咽困难。目前，有关血清急性期蛋白（APPs）在有症状的 CS 中的参与情况的信息有限。本研究的目的是研究 C 反应蛋白（CRP）、血清淀粉样蛋白 A（SAA）、触珠蛋白（Hp）和白蛋白是否参与 CS，以及入院时测量的浓度是否反映良性食管病变的严重程度。对 19 只自发性有症状食管旋毛虫病犬和 7 只临床健康犬进行回顾性研究。在有症状的犬中，最一致增加的 APP 是 Hp（95%的犬），其次是 CRP（68%）。SAA 浓度很少增加（5%的犬），而受影响的犬中有 58%的白蛋白浓度降低。旋毛虫病犬的 Hp（p=0.0001）和 CRP（p=0.02）中位数浓度明显高于健康犬。两组犬的白蛋白中位数浓度无差异。有单个或多个食管结节的犬之间，Hp、CRP 和白蛋白的中位数浓度无显著差异。本研究结果表明，在有症状的 CS 中，Hp 和 CRP 明显且一致地增加，而 SAA 和白蛋白作为诊断标志物的价值可能有限。入院时测量的 Hp、CRP 和白蛋白浓度与食管结节数量之间未建立相关性。
