Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 761001, Israel.
Laboratorio d'analisi Veterinarie "San Marco", Via Sorio 114/C, 35141 Padova, Italy.
Vet Parasitol. 2014 Jun 16;203(1-2):153-9. doi: 10.1016/j.vetpar.2014.02.001. Epub 2014 Feb 25.
Spirocerca lupi, the dog esophageal worm, typically induces formation of esophageal nodules, which may transform to sarcoma. Ante mortem discrimination between benign and malignant esophageal masses is challenging. Serum acute phase proteins (APPs) are utilized in diagnosis and prognosis of various canine diseases as markers of inflammation. This study characterized serum APPs concentrations in dogs with benign and malignant esophageal spirocercosis and evaluated their accuracy in differentiating benign from malignant lesions. Seventy-eight client-owned dogs with esophageal spirocercosis were included. Serum C-reactive protein (CRP), haptoglobin, serum-amyloid A (SAA) and albumin concentrations were measured upon diagnosis and follow-up visits, and compared with healthy dogs, and between malignant and benign cases. Haptoglobin, CRP and SAA concentrations were higher, and albumin concentration was lower (P<0.001 for all) in infected dogs compared to healthy controls. Dogs with suspected neoplasia had significantly higher CRP (P=0.011), haptoglobin (P=0.008) and SAA (P=0.05), and lower albumin (P=0.012) concentrations compared to dogs with benign esophageal nodules. APPs moderately discriminated between suspected malignant and benign esophageal disease. None of the dogs with suspected neoplasia had concurrent normal concentrations of all APPs. The present results indicate that canine spirocercosis is characterized by an acute phase reaction, both at presentation and during treatment. When concentrations of all four APPs are within reference range, esophageal malignancy is highly unlikely. Although concentrations of all positive APPs were significantly higher in suspected neoplastic cases compared to benign ones, moderate discriminatory power limits their clinical use. Neither APP was useful to monitor response to treatment.
犬食道丝虫（Spirocerca lupi）通常会导致食道结节形成，这些结节可能会转化为肉瘤。在生前区分良性和恶性食道肿块具有挑战性。血清急性期蛋白（APPs）作为炎症的标志物，被用于诊断和预测各种犬病。本研究对患有良性和恶性食道丝虫病的犬的血清 APP 浓度进行了特征描述，并评估了它们区分良性和恶性病变的准确性。本研究纳入了 78 只患有食道丝虫病的患犬。在诊断时和随访时测量了血清 C 反应蛋白（CRP）、触珠蛋白、血清淀粉样蛋白 A（SAA）和白蛋白浓度，并与健康犬进行了比较，同时还比较了良性和恶性病例之间的差异。与健康对照组相比，感染犬的触珠蛋白（P<0.001）、CRP（P<0.001）和 SAA（P<0.001）浓度较高，而白蛋白（P<0.001）浓度较低。疑似肿瘤的犬的 CRP（P=0.011）、触珠蛋白（P=0.008）和 SAA（P=0.05）浓度显著更高，白蛋白（P=0.012）浓度显著更低。APP 可以适度地区分疑似恶性和良性食道疾病。没有一只怀疑患有肿瘤的犬的所有 APP 浓度都在参考范围内。本研究结果表明，犬食道丝虫病的特征是急性期反应，无论是在发病时还是在治疗过程中。当所有四种 APP 的浓度均在参考范围内时，食道恶性肿瘤的可能性非常小。虽然疑似肿瘤病例中所有阳性 APP 的浓度均显著高于良性病例，但中度鉴别能力限制了其临床应用。没有一种 APP 可用于监测对治疗的反应。
