Department of Chemistry, King Saud University, Riyadh, Saudi Arabia.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Oct;96:179-87. doi: 10.1016/j.saa.2012.05.032. Epub 2012 May 22.
Phenylurea-formaldehyde polymer (PUF) was synthesized via polycondensation of phenylurea and formaldehyde in basic medium, its polymer-metal complexes [PUF-M(II)] were prepared with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions. PUF and PUF-M(II) were characterized with magnetic moment measurements, elemental and spectral (UV-visible, FTIR, 1H-NMR, 13C-NMR and ESR) analysis. The thermal behaviors of all the synthesized polymers were carried out using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The thermal data revealed that all of the PUF-M(II) showed higher thermal stabilities than the PUF and also ascribed that the PUF-Cu(II) showed better thermal stability than the other PUF-M(II). The kinetic parameters such as activation energy, pre-exponential factor etc., were evaluated for these polymer metal complexes using Coats-Redfern equation. In addition, the antimicrobial activity of the synthesized polymers was tested against several microorganisms using agar well diffusion methods. Among all of the PUF-M(II), the antimicrobial activity of the PUF-Cu(II) showed the highest zone of inhibition because of its higher stability constant and may be used in biomedical applications.
通过在碱性介质中缩合苯脲和甲醛合成了苯脲-甲醛聚合物（PUF），并制备了其聚合物-金属配合物[PUF-M（II）]，其中 M(II) 代表 Mn(II)、Co(II)、Ni(II)、Cu(II)和 Zn(II)离子。通过磁矩测量、元素分析和光谱（UV-可见、FTIR、1H-NMR、13C-NMR 和 ESR）分析对 PUF 和 PUF-M（II）进行了表征。使用热重分析（TGA）和差示热分析（DTA）对所有合成聚合物的热行为进行了研究。热数据表明，所有 PUF-M（II）的热稳定性均高于 PUF，并且还归因于 PUF-Cu（II）比其他 PUF-M（II）具有更好的热稳定性。使用 Coats-Redfern 方程评估了这些聚合物金属配合物的动力学参数，如活化能、指数前因子等。此外，还使用琼脂孔扩散法测试了合成聚合物对几种微生物的抗菌活性。在所有的 PUF-M（II）中，由于其较高的稳定常数，PUF-Cu（II）的抑菌活性最高，可能用于生物医学应用。
