Materials Research Lab, Department of Chemistry Jamia Millia Islamia, New Delhi 110025, India.
Eur J Med Chem. 2010 Apr;45(4):1287-94. doi: 10.1016/j.ejmech.2009.11.047.
Semicarbazide-formaldehyde resin (SFRs) was prepared by the condensation of semicarbazide with formaldehyde in an acidic medium and its polymer metal complexes were prepared with transition metal ions. All the synthesized polymers were characterized by elemental analysis, FTIR, (1)H NMR, (13)C NMR, electronic spectroscopy, magnetic moment measurement and thermogravimetric analyses. The percentage of metal in all the polymer metal complexes was found to be consistent with 2:1 (resin: metal) stoichiometry. The magnetic susceptibility measurement and electronic spectra of all the polymer metal complexes confirmed the geometry of the complexes. All the synthesized polymeric compounds have been screened in vitro against Bacillus subtilis, Staphylococcus aureus (Gram-positive) and Escherichia coli, Salmonella typhi (Gram-negative) using shaking flask method. The entire polymer metal complexes showed excellent anti-bacterial activity and low toxicity when compared with their parental polymeric resin. The anti-bacterial activity and toxicity of the entire synthesized compound is significant and they can be used as antimicrobial as well as anticancer agents for mammals in future.
氨基脲-甲醛树脂（SFRs）是由氨基脲与甲醛在酸性介质中缩合而成的，其聚合物金属配合物是由过渡金属离子制备的。所有合成的聚合物都通过元素分析、FTIR、（1）H NMR、（13）C NMR、电子光谱、磁矩测量和热重分析进行了表征。所有聚合物金属配合物中的金属百分比都与 2:1（树脂：金属）化学计量一致。所有聚合物金属配合物的磁化率测量和电子光谱都证实了配合物的几何形状。所有合成的聚合物化合物都使用摇瓶法在体外对枯草芽孢杆菌、金黄色葡萄球菌（革兰氏阳性）和大肠杆菌、伤寒沙门氏菌（革兰氏阴性）进行了筛选。与母体聚合物树脂相比，所有聚合物金属配合物都表现出优异的抗菌活性和低毒性。整个合成化合物的抗菌活性和毒性都很显著，将来它们可以作为抗菌剂和抗癌剂用于哺乳动物。
