Yamanouchi Kosho, Takatsuki Mitsuhisa, Hidaka Masaaki, Soyama Akihiko, Miyazaki Kensuke, Inokuma Takamitsu, Muraoka Izumi, Kanematsu Takashi, Eguchi Susumu
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hepatogastroenterology. 2012 Jul-Aug;59(117):1569-72. doi: 10.5754/hge10008.
BACKGROUND/AIMS: Quality of life has become important as an outcome in addition to conventional outcomes such as disease-free and overall survival. In this study, we compared the fluctuations of quality of life after hepatectomy and living donor liver transplantation.
Thirteen adult patients undergoing hepatectomy and 7 with living donor liver transplantation were enrolled. The SF-36, which can objectively measure health-related generic physical and mental quality of life, was completed before surgery and at 3, 6, 9 and 12 months after surgery.
Before surgery, the scores of 7 out of 8 domains in SF36 were significantly lower in the transplantation group than in the hepatectomy group. After hepatectomy, quality of life dropped temporarily and subsequently gradually recovered toward the baseline, while after transplantation, quality of life, especially mental function, tended to be improved beyond the baseline. Consequently, the quality of life of the transplantation patients became comparable to that of the hepatectomy patients 12 months after surgery.
Living donor liver transplantation was demonstrated to be a sensible therapeutic intervention for liver failure and malignances from the point of view of improvement in physical and mental quality of life.
背景/目的：除了无病生存和总生存等传统结局外，生活质量已成为一个重要的结局指标。在本研究中，我们比较了肝切除术后和活体肝移植术后生活质量的波动情况。
纳入13例接受肝切除术的成年患者和7例接受活体肝移植的患者。使用SF-36量表，该量表可客观测量与健康相关的一般身体和心理生活质量，分别在手术前以及术后3、6、9和12个月完成测评。
术前，移植组SF-36量表8个领域中的7个领域得分显著低于肝切除组。肝切除术后，生活质量暂时下降，随后逐渐恢复至基线水平，而移植术后，生活质量，尤其是心理功能，趋于改善并超过基线水平。因此，术后12个月时，移植患者的生活质量与肝切除患者相当。
从改善身心生活质量的角度来看，活体肝移植被证明是治疗肝衰竭和恶性肿瘤的一种明智的治疗干预措施。
