Research Laboratory of Applied Microbiology, Federal University of Ceará, Ceará, Fortaleza, Brazil.
Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):2887-95. doi: 10.1007/s10096-012-1660-4. Epub 2012 Jun 9.
The immune defence against Mycobacterium tuberculosis is complex and involves multiple interacting cells. Studies in subjects with polymorphisms in genes for IFN or its receptor gene evaluate their relationship with mycobacterium infections. The purpose of this study was to analyze the evidence of the effect of polymorphism +874 A/T from interferon-γ on the occurrence of tuberculosis. We performed a meta-analysis of studies published between June 2002 and April 2012. The articles analyzed assessed the relationship between the polymorphism +874 A/T and the development of tuberculosis. The meta-analysis was performed with a random effect model, considering the heterogeneity among studies. Genotype TT showed a protective effect (OR, 0.77; 95% CI = 0.67-0.88) while genotype AA may be associated with increased susceptibility to developing tuberculosis (OR, 1.51; 95% CI = 1.38-1.65). In relation to alleles, we can verify that the A allele is related to the development of tuberculosis (OR, 1.56; 95% CI = 1.42-1.71). This information reinforces the importance of host genetics in the development of infectious diseases. Studies in this area can result in the promotion of new and more accurate genetic markers.
针对结核分枝杆菌的免疫防御机制复杂，涉及多种相互作用的细胞。在干扰素（IFN）及其受体基因存在多态性的研究对象中，评估这些多态性与分枝杆菌感染的关系。本研究旨在分析干扰素-γ基因+874 A/T 多态性对结核病发生的影响。我们对 2002 年 6 月至 2012 年 4 月间发表的研究进行了荟萃分析。分析的文章评估了+874 A/T 多态性与结核病发展之间的关系。荟萃分析采用随机效应模型，考虑了研究之间的异质性。TT 基因型显示出保护作用（OR，0.77；95%CI=0.67-0.88），而 AA 基因型可能与结核易感性增加相关（OR，1.51；95%CI=1.38-1.65）。关于等位基因，我们可以发现 A 等位基因与结核病的发生有关（OR，1.56；95%CI=1.42-1.71）。这一信息强调了宿主遗传学在传染病发生中的重要性。该领域的研究可以促进新的、更准确的遗传标志物的产生。
