Growth, Exercise, Nutrition and Development Research Group, Department of Physiatry and Nursing, Faculty of Health and Sport Sciences, FCSD, University of Zaragoza, Huesca, Spain.
Osteoporos Int. 2013 Mar;24(3):1035-44. doi: 10.1007/s00198-012-2041-7. Epub 2012 Jun 9.
We aimed to describe the structure and strength of the tibia and radius of adolescents with Down syndrome. We observed that despite higher levels of volumetric bone mineral density in determined skeletal sites, they are at higher risk of developing osteoporotic fractures in the future due to their lower bone strength indexes.
The aims of the study were to describe the cortical and trabecular volumetric bone mineral density (vBMD), bone mineral content (BMC), area, and bone strength in adolescents with Down syndrome (DS) and to compare them with adolescents without disabilities.
Thirty adolescents (11 girls) with DS and 28 without disabilities (10 girls) participated in the study. Peripheral quantitative computed tomography measurements were taken at proximal and distal sites of the tibia and radius. Values of total, trabecular, and cortical BMC; vBMD; and area were obtained of each scan. Cortical thickness and endosteal and periosteal circumferences were also measured, and different bone strength indexes were calculated. Student's t tests were applied between groups.
The DS group showed greater vBMD at distal radius, BMC at proximal radius, and total and cortical vBMD at proximal tibia. The non-DS group showed higher total and trabecular area at the distal radius and total, cortical, and trabecular BMC and area at distal tibia. Higher values of periosteal and endosteal circumference and bone strength were also found in non-DS group.
From these results, it can be believed that even with higher vBMD in determined skeletal sites, adolescents with DS are at higher risk of suffering bone fractures due to an increased fragility by lower resistance to load bending or torsion.
描述唐氏综合征青少年的胫骨和桡骨结构和强度。我们发现，尽管某些骨骼部位的体积骨密度较高，但由于骨强度指标较低，他们未来发生骨质疏松性骨折的风险更高。
本研究旨在描述唐氏综合征（DS）青少年的皮质骨和小梁体积骨密度（vBMD）、骨矿物质含量（BMC）、面积和骨强度，并将其与无残疾青少年进行比较。
30 名唐氏综合征青少年（11 名女孩）和 28 名无残疾青少年（10 名女孩）参与了这项研究。在胫骨和桡骨的近端和远端部位进行了外周定量计算机断层扫描测量。获得了每个扫描的总、小梁和皮质 BMC；vBMD；和面积的值。还测量了皮质厚度以及内、外周长，并计算了不同的骨强度指数。对两组之间进行了学生 t 检验。
DS 组在桡骨远端、桡骨近端 BMC 和胫骨近端总骨和皮质 vBMD 方面表现出更高的值。非 DS 组在桡骨远端总骨和小梁面积以及胫骨远端总骨、皮质和小梁 BMC 和面积方面表现出更高的值。非 DS 组还发现了更高的骨外周长和骨内周长以及骨强度值。
从这些结果可以看出，即使在某些骨骼部位的 vBMD 较高的情况下，由于对弯曲或扭转负荷的抵抗力较低导致的脆性增加，唐氏综合征青少年仍有更高的骨折风险。
