GENUD (Growth, Exercise, Nutrition and Development) research group, University of Zaragoza, Ed. Cervantes. Corona de Aragón St. 42, 2nd floor, 50009, Zaragoza, Spain.
Osteoporos Int. 2011 Jul;22(7):2151-7. doi: 10.1007/s00198-010-1443-7. Epub 2010 Oct 22.
Children and adolescents with Down syndrome (DS) have lower levels of bone mass compared with youths without DS. Their sexual dimorphism in bone mass also differs from that observed in children and adolescents without Down syndrome.
This study aimed to compare bone mass and sexual dimorphism in bone mass between male and female youths with DS and age- and sex-matched controls without DS.
Bone mineral density (BMD), volumetric BMD, bone mineral apparent density (BMAD), BMD/height (BMDH), and total lean mass were measured or calculated from DXA. Thirty-two youths (15 females) with DS and 32 youths (13 females) without DS participated in the study.
ANOVA tests showed lower BMAD and BMDH in females with DS compared with females without DS. ANCOVA tests revealed lower BMD in the whole body of males and females as well as BMD in the hip region of the females with DS compared with their counterparts without DS. Within the group with DS, females had greater lumbar spine BMD than the males.
The low values of BMD and related parameters, together with the differences in the sexual dimorphism, indicate a non-standard bone development in this specific population of children and adolescents with DS.
与非唐氏综合征（DS）青少年相比，唐氏综合征患儿的骨量较低。他们的骨量性别二态性也与非唐氏综合征儿童和青少年的观察结果不同。
本研究旨在比较男性和女性唐氏综合征青少年与年龄和性别匹配的无唐氏综合征对照组之间的骨量和骨量性别二态性。
使用 DXA 测量或计算骨矿物质密度（BMD）、体积 BMD、骨矿物质表观密度（BMAD）、BMD/身高（BMDH）和总瘦体重。32 名唐氏综合征青少年（15 名女性）和 32 名非唐氏综合征青少年（13 名女性）参与了这项研究。
方差分析显示，唐氏综合征女性的 BMAD 和 BMDH 低于非唐氏综合征女性。协方差分析显示，唐氏综合征男性和女性的全身 BMD 以及女性的髋部 BMD 低于非唐氏综合征对照组。在唐氏综合征组内，女性的腰椎 BMD 高于男性。
BMD 及相关参数值较低，以及性别二态性的差异，表明该特定唐氏综合征儿童和青少年群体的骨骼发育不正常。
