Centro de Investigación Científica de Yucatán, A.C., Calle 43 # 130 Col. Chuburná de Hidalgo, Mérida, Yucatán, México.
J Biomater Appl. 2013 Aug;28(2):270-7. doi: 10.1177/0885328212448259. Epub 2012 Jun 7.
Biodegradable segmented polyurethanes were prepared with poly(caprolactone) diol as a soft segment, 4,4'-methylene bis(cyclohexyl isocyanate) (HMDI) and either butanediol or dithioerythritol as chain extenders. Platelet adhesion was similar in all segmented polyurethanes studied and not different from Tecoflex® although an early stage of activation was observed on biodegradable segmented polyurethane prepared with dithioerythritol. Relative viability was higher than 80% on human umbilical vein endothelial cells in contact with biodegradable segmented polyurethane extracts after 1, 2 and 7 days. Furthermore, both biodegradable segmented polyurethane materials supported human umbilical vein endothelial cell adhesion, spreading, and viability similar to Tecoflex® medical-grade polyurethane. These biodegradable segmented polyurethanes represent promising materials for cardiovascular applications.
可生物降解的嵌段型聚氨基甲酸酯由聚己内酯二醇作为软段、4,4'-亚甲基双(环己基异氰酸酯)(HMDI)以及丁二醇或二硫赤藓糖醇作为扩链剂制备而成。在所研究的所有嵌段型聚氨基甲酸酯中，血小板黏附情况相似，与 Tecoflex®无差异，尽管在用二硫赤藓糖醇制备的可生物降解的嵌段型聚氨基甲酸酯上观察到早期的激活阶段。在与可生物降解的嵌段型聚氨基甲酸酯提取物接触 1、2 和 7 天后，接触到的人脐静脉内皮细胞的相对存活率高于 80%。此外，两种可生物降解的嵌段型聚氨基甲酸酯材料均支持人脐静脉内皮细胞黏附、铺展和存活，与 Tecoflex®医用级聚氨基甲酸酯相似。这些可生物降解的嵌段型聚氨基甲酸酯是心血管应用的有前途的材料。
