Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan.
Stem Cell Rev Rep. 2013 Aug;9(4):422-34. doi: 10.1007/s12015-012-9388-1.
Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells.
胚胎干细胞 (ES) 和诱导多能干细胞 (iPS) 可在合适的培养环境中分化为任何类型的组织，被认为是再生医学的有价值的工具。在血液学领域，通过中胚层细胞（HC 的祖细胞）从 ES 和 iPS 细胞生成造血干细胞 (HSC) 和成熟的造血细胞 (HC)，可促进移植和输血治疗。一些研究报告称，从鼠和人 ES 和 iPS 细胞中生成了功能齐全的 HC。该方法将来很可能应用于个体患者来源的 iPS 细胞，用于再生医学方法和药物筛选。在这里，我们总结了目前 ES 和 iPS 细胞生成 HC 的研究。
