血液学领域细胞技术的进展：我们目前了解到了什么？
Advances in cellular technology in the hematology field: What have we learned so far?
作者信息
de Souza Gustavo Torres, Maranduba Claudinéia Pereira, de Souza Camila Maurmann, do Amaral Danielle Luciana Aurora Soares, da Guia Francisco Carlos, Zanette Rafaella de Souza Salomão, Rettore João Vitor Paes, Rabelo Natana Chaves, Nascimento Lucas Mendes, Pinto Ícaro França Navarro, Farani Júlia Boechat, Neto Abrahão Elias Hallack, Silva Fernando de Sá, Maranduba Carlos Magno da Costa, Atalla Angelo
机构信息
Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
出版信息
World J Stem Cells. 2015 Jan 26;7(1):106-15. doi: 10.4252/wjsc.v7.i1.106.
Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-the-art concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.
尽管血液学领域取得了进展，但由于血液抗原不相容性，输血相关的医源性问题在这些操作过程中仍是一个需要考虑的主要问题。这使得多能干细胞成为生产更合适血液制品的可能盟友。本综述文章旨在全面总结关于胚胎干细胞和诱导多能干细胞向造血细胞系分化的最新进展。在此，我们回顾了最近发表的用于生产血细胞的方案，以便未来应用于血液治疗、癌症治疗和基础研究。
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