人冠状动脉和人隐静脉对5-羟色胺的收缩反应。
Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein.
作者信息
Borton M, Neligan M, Wood F, Dervan P, Goggins K, Docherty J R
机构信息
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
出版信息
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):107S-108S. doi: 10.1111/j.1365-2125.1990.tb05476.x.
Abstract
Isometric contractions were obtained to 5-hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5-HT2 receptor antagonist ketanserin, both 5-HT1 and 5-HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5-HT1 receptor.
摘要
在人隐静脉和人冠状动脉中获得了对5-羟色胺受体激动剂的等长收缩。基于与5-HT2受体拮抗剂酮色林的相互作用，5-HT1和5-HT2受体均参与人隐静脉的收缩，但参与人冠状动脉收缩的主要亚型是5-HT1受体。
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