人隐静脉中5-羟色胺受体的检测
An examination of 5-hydroxytryptamine receptors in human saphenous vein.
作者信息
Docherty J R, Hyland L
出版信息
Br J Pharmacol. 1986 Sep;89(1):77-81. doi: 10.1111/j.1476-5381.1986.tb11122.x.
Abstract
We have examined the effects of antagonists on the isometric contraction of the human saphenous vein produced by 5-hydroxytryptamine (5-HT). The 5-HT2-antagonist ketanserin (1 microM) had little effect on the lower part of the concentration-response curve to 5-HT, but markedly shifted the upper part of the curve. Yohimbine caused an approximately parallel shift of the concentration-response curve to 5-HT, with a pA2 of 5.48, much lower than its pA2 against noradrenaline in the absence (6.36) or presence (7.06) of cocaine. It is concluded that there are two components to the contractile response to 5-HT in human saphenous vein: at low concentrations 5-HT activates a yohimbine-sensitive receptor, and at higher concentrations 5-HT activates a 5-HT2-receptor.
摘要
我们研究了拮抗剂对5-羟色胺（5-HT）引起的人隐静脉等长收缩的影响。5-HT2拮抗剂酮色林（1微摩尔）对5-HT浓度-反应曲线的下部影响很小，但使曲线的上部明显上移。育亨宾使5-HT浓度-反应曲线近似平行上移，其pA2为5.48，远低于其在不存在（6.36）或存在（7.06）可卡因时对去甲肾上腺素的pA2。结论是人隐静脉对5-HT的收缩反应有两个成分：低浓度时5-HT激活对育亨宾敏感的受体，高浓度时5-HT激活5-HT2受体。
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本文引用的文献
1
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
2
Neuronal 5-HT receptors in the periphery.外周的神经元5-羟色胺受体。
Neuropharmacology. 1984 Dec;23(12B):1473-86. doi: 10.1016/0028-3908(84)90091-1.
3
MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.MDL 72222：一种强效且高度选择性的神经元5-羟色胺受体拮抗剂。
Naunyn Schmiedebergs Arch Pharmacol. 1984 May;326(1):36-44. doi: 10.1007/BF00518776.
4
Vascular serotonin receptors. Correlation with 5-HT1 and 5-HT2 binding sites.血管血清素受体。与5-HT1和5-HT2结合位点的相关性。
Biochem Pharmacol. 1984 Aug 1;33(15):2349-53. doi: 10.1016/0006-2952(84)90704-4.
5
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.8-羟基-2-（二正丙基氨基）四氢萘可区分5-HT1识别位点的亚型。
Eur J Pharmacol. 1983 May 20;90(1):151-3. doi: 10.1016/0014-2999(83)90230-3.
6
Postsynaptic alpha-adrenoceptor subtypes in rabbit blood vessels and rat anococcygeus muscle studied in vitro.体外研究兔血管和大鼠肛尾肌中的突触后α-肾上腺素能受体亚型。
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7
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