Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NO-7489, Norway.
Psychosom Med. 2012 Jun;74(5):543-53. doi: 10.1097/PSY.0b013e31825904eb.
To explore the hypothesis that insomnia may increase the risk of coronary heart disease through inflammatory mechanisms.
The association of high-sensitivity C-reactive protein (hsCRP) with self-reported symptoms of insomnia was examined. Participants were 8547 men and nonpregnant women who answered one or more insomnia-related questions and who had available hsCRP measurements in the Nord-Trøndelag Health Study. In multivariable linear regression analyses of the logarithm of hsCRP, we adjusted for established cardiovascular risk factors, psychosocial distress, chronic pain, and chronic somatic disorders.
Among men, difficulties initiating sleep and nonrestorative sleep were associated with increasing hsCRP levels after adjusting for age (B = 0.07, 95% confidence interval [CI] = 0.01-0.14, p for trend = .02 and B = 0.09, 95% CI = 0.02-0.15, p for trend = .006), but after multivariable adjustment, the associations were attenuated (B = 0.03, 95% CI = -0.03 to 0.09, p for trend = .30 and B = 0.06, 95% CI = -0.00 to 0.12, p for trend = .05). HsCRP was not associated with other insomnia-related symptoms. In women, there was no evidence for any association of symptoms of insomnia with hsCRP levels. Results indicated sex differences in the association between sleep characteristics and CRP (difficulties maintaining sleep, p interaction = .018; cumulative number of symptoms of insomnia, p interaction = .014; and symptoms of insomnia influencing work performance, p interaction = .039).
There were no consistent associations between symptoms of insomnia and hsCRP levels. Our results do not support the hypothesis that inflammation, as reflected by elevated levels of hsCRP, is an important factor linking insomnia to coronary heart disease.
探讨失眠可能通过炎症机制增加冠心病风险的假说。
检查高敏 C 反应蛋白（hsCRP）与自述失眠症状之间的关联。参与者为 8547 名男性和非孕妇，他们回答了一个或多个与失眠相关的问题，并且在北特伦德拉格健康研究中可获得 hsCRP 测量值。在多变量线性回归分析中，我们对 hsCRP 的对数进行了调整，以调整已确定的心血管风险因素、心理社会压力、慢性疼痛和慢性躯体疾病。
在男性中，入睡困难和睡眠质量差与 hsCRP 水平升高相关，调整年龄后（B = 0.07，95%置信区间[CI] = 0.01-0.14，p 趋势 =.02 和 B = 0.09，95%CI = 0.02-0.15，p 趋势 =.006），但在多变量调整后，关联减弱（B = 0.03，95%CI = -0.03 至 0.09，p 趋势 =.30 和 B = 0.06，95%CI = -0.00 至 0.12，p 趋势 =.05）。hsCRP 与其他与失眠相关的症状无关。在女性中，没有证据表明失眠症状与 hsCRP 水平之间存在任何关联。结果表明，睡眠特征与 CRP 之间的关联存在性别差异（维持睡眠困难，p 交互 =.018；失眠症状的累积数量，p 交互 =.014；以及失眠症状影响工作表现，p 交互 =.039）。
失眠症状与 hsCRP 水平之间没有一致的关联。我们的结果不支持炎症（如 hsCRP 水平升高所反映的）是将失眠与冠心病联系起来的重要因素的假说。
