Psychobiology of Stress & Health Laboratory, Psychology Department, Mount Allison University, Sackville, Canada.
Eur J Prev Cardiol. 2012 Aug;19(4):857-63. doi: 10.1177/1741826711415720. Epub 2011 Jul 5.
This study examined whether mild-to-moderate depressive symptoms are associated with increased high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) levels in apparently healthy individuals at high risk for coronary artery disease. We investigated in individuals whether: (1) current depressive symptoms were associated with increased hsCRP and IL-6 levels; (2) persistent depressive symptoms at two time points 6 months apart were associated with hsCRP and IL-6; and (3), sex-based differences in inflammation were a function of depressive symptoms.
We measured depressive symptoms (twice), hsCRP, and IL-6 (follow-up time point) in 84 apparently healthy individuals (52% women) at high cardiac risk.
Patients with persistent depressive symptoms had higher hsCRP, compared to participants without persistent symptoms (5.55 vs. 1.70 mg/l, p < 0.05, 95% CI 0.11 to 1.09, d = 0.67). Participants with current depressive symptoms had higher hsCRP (3.99 vs. 1.70 mg/l, p = 0.059) than those without symptoms. Findings remained unchanged after controlling for covariates. Women had higher adjusted hsCRP than men (2.91 vs. 1.87 mg/l, p < 0.001). When we entered depressive symptoms, the model remained significant, with a significant interaction between sex and symptoms: women with depressive symptoms had higher hsCRP than men with depressive symptoms and than women without symptoms (6.75 vs. 1.11 mg/l). The hypothesized differences were not observed with respect to IL-6, after controlling for body mass index (95% CI-0.77 to 0.73).
Before a first ischaemic coronary event, persistent mild-to-moderate depressive symptoms were associated with increased hsCRP. Women with depressive symptoms had higher hsCRP than men with symptoms.
本研究旨在探讨在有发生冠心病高危因素但表面健康的个体中，轻中度抑郁症状是否与高敏 C 反应蛋白（hsCRP）和白细胞介素 6（IL-6）水平升高有关。我们研究了以下几方面：（1）当前的抑郁症状是否与 hsCRP 和 IL-6 水平升高有关；（2）相隔 6 个月的两次抑郁症状持续存在是否与 hsCRP 和 IL-6 相关；（3）性别不同与炎症相关的原因是否与抑郁症状有关。
我们对 84 名高心脏风险的表面健康个体（52%为女性）进行了两次抑郁症状测量（随访时间点测量 hsCRP 和 IL-6）。
与无持续症状的患者相比，持续性抑郁症状患者 hsCRP 水平更高（5.55 比 1.70mg/L，p<0.05，95%CI 0.11 至 1.09，d=0.67）。当前有抑郁症状的患者 hsCRP 水平更高（3.99 比 1.70mg/L，p=0.059）。调整了协变量后，结果仍然不变。女性 hsCRP 水平高于男性（2.91 比 1.87mg/L，p<0.001）。当我们引入抑郁症状时，模型仍然显著，性别与症状之间存在显著的交互作用：有抑郁症状的女性 hsCRP 水平高于有抑郁症状的男性和无症状的女性（6.75 比 1.11mg/L）。控制了体重指数后，并未观察到 IL-6 方面的假设差异（95%CI-0.77 至 0.73）。
在首次发生缺血性冠状动脉事件之前，持续性轻中度抑郁症状与 hsCRP 升高有关。有抑郁症状的女性 hsCRP 水平高于有症状的男性。
