Fong Peying
Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, 1600 Denison Avenue, Manhattan, KS 66506, USA.
Biophys Rev. 2012 Jun 1;4(2):107-116. doi: 10.1007/s12551-012-0068-9. Epub 2012 Feb 15.
Transport mechanisms that mediate the movements of anions must be coordinated tightly in order to respond appropriately to physiological stimuli. This process is of paramount importance in the function of diverse epithelial tissues of the body, such as, for example, the exocrine pancreatic duct and the airway epithelia. Disruption of any of the finely tuned components underlying the transport of anions such as Cl(-), HCO(3) (-), SCN(-), and I(-) may contribute to a plethora of disease conditions. In many anion-secreting epithelia, the interactions between the cystic fibrosis transmembrane conductance regulator (CFTR) and solute carrier family 26 (SLC26) transporters determine the final exit of anions across the apical membrane and into the luminal compartment. The molecular identification of CFTR and many SLC26 members has enabled the acquisition of progressively more detailed structural information about these transport molecules. Studies employing a vast array of increasingly sophisticated approaches have culminated in a current working model which places these key players within an interactive complex, thereby setting the stage for future work.
介导阴离子转运的机制必须紧密协调，以便对生理刺激做出适当反应。这一过程在身体各种上皮组织的功能中至关重要，例如外分泌胰腺导管和气道上皮。破坏任何参与阴离子（如Cl(-)、HCO(3) (-)、SCN(-)和I(-)）转运的精细调节成分都可能导致多种疾病状态。在许多阴离子分泌上皮中，囊性纤维化跨膜电导调节因子（CFTR）和溶质载体家族26（SLC26）转运体之间的相互作用决定了阴离子最终穿过顶端膜进入管腔隔室。CFTR和许多SLC26成员的分子鉴定使得能够获得关于这些转运分子越来越详细的结构信息。采用大量日益复杂方法的研究最终形成了一个当前的工作模型，该模型将这些关键参与者置于一个相互作用的复合体中，从而为未来的工作奠定了基础。
