Sakata Hiroshi
Department of Pediatrics, Asahikawa Kosei Hospital.
Jpn J Antibiot. 2011 Dec;64(6):383-7.
The clinical effect of peramivir was examined retrospectively in 30 children aged 23 days to 8 years; they had been treated with peramivir at our hospital within 48 hours after the onset of influenza from November 2010 to April 2011. Intravenous dripping of peramivir at a dose of 10 mg/kg was performed only once for 15 to 30 minutes. To examine the clinical effect of peramivir, the time from dosing to defervescence (body temperature <37.5 degrees C) was evaluated. To compare the clinical effects of peramivir and oseltamivir, the time required for the defervescence was evaluated in a similar manner in 30 children aged 7 months to 8 years who had been treated for influenza with oseltamivir at a dose of 4 mg/kg/day. The influenza type was type A (n=25) and type B (n=5) in the peramivir group and type A (n=26) and type B (n=4) in the oseltamivir group. In the peramivir group, 5 (16.7%), 16 (53.3%), and 24 (80.0%) patients achieved defervescence within 6, 12, and 24 hours, respectively. In the oseltamivir group, 3 (10.0%) and 6 (20.0%) patients had defervescence within 12 and 24 hours, respectively. The difference between these groups was statistically significant (p<0.05). An increase in the levels of AST and ALT was observed as an adverse reaction in 1 patient. Thus, peramivir was determined to be effective to influenza in children.
回顾性研究了30名年龄在23天至8岁的儿童使用帕拉米韦的临床效果；这些儿童于2010年11月至2011年4月在我院流感发病后48小时内接受了帕拉米韦治疗。仅以10mg/kg的剂量静脉滴注帕拉米韦一次，持续15至30分钟。为了研究帕拉米韦的临床效果，评估了给药至退热（体温<37.5摄氏度）的时间。为了比较帕拉米韦和奥司他韦的临床效果，以类似方式评估了30名年龄在7个月至8岁、接受4mg/kg/天奥司他韦治疗流感的儿童的退热所需时间。帕拉米韦组的流感类型为甲型（n=25）和乙型（n=5），奥司他韦组为甲型（n=26）和乙型（n=4）。在帕拉米韦组中，分别有5名（16.7%）、16名（53.3%）和24名（80.0%）患者在6、12和24小时内退热。在奥司他韦组中，分别有3名（10.0%）和6名（20.0%）患者在12和24小时内退热。两组之间的差异具有统计学意义（p<0.05）。1例患者出现AST和ALT水平升高的不良反应。因此，确定帕拉米韦对儿童流感有效。
