Department of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland.
Acta Oncol. 2012 Sep;51(7):822-30. doi: 10.3109/0284186X.2012.689113. Epub 2012 Jun 11.
The endoplasmic reticulum (ER) orchestrates the production of membrane-bound and secreted proteins. However, its capacity to process the synthesis and folding of protein is limited. Protein overload and the accumulation of misfolded proteins in the ER trigger an adaptive response known as the ER-stress response that is mediated by specific ER-anchored signaling pathways. This response regulates cell functions aimed at restoring cellular homeostasis or at promoting apoptosis of irreparably damaged cells. Activation or deregulation of ER-signaling pathways has been associated with various diseases including cancer. Here we discuss how tumors engage ER-signaling pathways to promote tumorigenesis and how manipulation of this process by anticancer drugs may contribute to cancer treatment.
内质网（ER）协调膜结合蛋白和分泌蛋白的产生。然而，其处理蛋白质合成和折叠的能力是有限的。蛋白质过载和错误折叠的蛋白质在 ER 中的积累触发了一种适应性反应，称为 ER 应激反应，它是由特定的 ER 锚定信号通路介导的。该反应调节旨在恢复细胞内稳态或促进不可修复损伤细胞凋亡的细胞功能。ER 信号通路的激活或失调与包括癌症在内的各种疾病有关。在这里，我们讨论了肿瘤如何利用 ER 信号通路促进肿瘤发生，以及抗癌药物对这一过程的操纵如何有助于癌症治疗。
