Oluyemi Aderemi, Anomneze Ebere, Smith Stella, Fasanmade Olufemi
General Hospital, Ikorodu, Lagos State, Nigeria.
BMC Res Notes. 2012 Jun 11;5:284. doi: 10.1186/1756-0500-5-284.
There appears to exist a potentially important interplay between diabetes mellitus (DM) and Helicobacter pylori (H. pylori) infection. Findings from previous studies have been conflicting. Only a few studies have examined the topic in a sub-Saharan African population. This study sought to determine the prevalence of H. pylori infection among Type 2 diabetes mellitus (T2DM) patients in Lagos, Nigeria.
H. pylori infection was detected in 18% of T2DM patients and 13% of controls but there was no statistical significance in this difference (p = 0.52). The prevalence of H. pylori was neither associated with the known duration of T2DM nor was it associated with age, gender, body mass index (BMI), smoking status. T2DM was not shown to be a risk factor independently associated with risk for H. pylori infection (OR = 0.87, 95% CI = 0.58-1.31, p = 0.57).
The lack of a statistical significant difference between the H. pylori infection rates in T2DM patients and controls suggests that the infection is not increased in T2DM. Larger studies need to be conducted to confirm the study findings.
糖尿病（DM）与幽门螺杆菌（H. pylori）感染之间似乎存在潜在的重要相互作用。以往研究的结果相互矛盾。只有少数研究在撒哈拉以南非洲人群中探讨过这一话题。本研究旨在确定尼日利亚拉各斯2型糖尿病（T2DM）患者中幽门螺杆菌感染的患病率。
在18%的T2DM患者和13%的对照组中检测到幽门螺杆菌感染，但这种差异无统计学意义（p = 0.52）。幽门螺杆菌的患病率既与已知的T2DM病程无关，也与年龄、性别、体重指数（BMI）、吸烟状况无关。未显示T2DM是与幽门螺杆菌感染风险独立相关的危险因素（OR = 0.87，95%CI = 0.58 - 1.31，p = 0.57）。
T2DM患者与对照组幽门螺杆菌感染率之间缺乏统计学显著差异，表明T2DM患者的感染并未增加。需要开展更大规模的研究以证实本研究结果。
