Long Dan, Mao Chenhan, Xu Yin, Zhu Ying
Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Front Endocrinol (Lausanne). 2025 Apr 22;16:1443705. doi: 10.3389/fendo.2025.1443705. eCollection 2025.
Mounting research suggests that insulin resistance (IR) is associated with () infection. The triglyceride-glucose (TyG) index has received widespread attention due to its high sensitivity in assessing IR. This study examined the association between infection and TyG index.
This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 1999 - 2000. Participants were categorized into quartile groups (Q1-Q4) based on their TyG index. Weighted multivariable-adjusted logistic regression and subgroup analysis were used to explore the correlation between TyG index and infection. Furthermore, sensitivity analysis was conducted to assess the robustness of our findings.
This study included 2,918 participants, 1,101 of whom were infected with . The mean TyG index for all participants was 8.56 ± 0.67. Patients who were positive had higher levels of TyG index compared with seronegative participants (8.74 ± 0.03 vs. 8.57 ± 0.03, < 0.05). The fourth quartile of the TyG index showed the highest odds of infection compared to Q1 (OR = 2.37, 95%CI: 1.52 to 3.71, < 0.001). Sensitivity analysis indicated that the association between TyG index and infection remained strong even after excluding participants with cardiovascular diseases or taking lipid-lowering medications, as well as patients with diabetes or taking glucose-lowering medications.
In this study, a stable and strong positive association was found between TyG index and infection. IR may be significantly associated with infection. Further studies are necessary to elucidate the underlying mechanisms and potential clinical implications of these findings.
越来越多的研究表明胰岛素抵抗（IR）与（）感染有关。甘油三酯-葡萄糖（TyG）指数因其在评估IR方面的高敏感性而受到广泛关注。本研究探讨了（）感染与TyG指数之间的关联。
这项横断面研究使用了1999 - 2000年美国国家健康与营养检查调查（NHANES）的数据。参与者根据其TyG指数被分为四分位数组（Q1 - Q4）。采用加权多变量调整逻辑回归和亚组分析来探讨TyG指数与（）感染之间的相关性。此外，进行了敏感性分析以评估我们研究结果的稳健性。
本研究纳入了2918名参与者，其中1101人感染了（）。所有参与者的平均TyG指数为8.56±0.67。与（）血清阴性参与者相比，（）阳性患者的TyG指数水平更高（8.74±0.03对8.57±0.03，<0.05）。与Q1相比，TyG指数的第四个四分位数显示（）感染的几率最高（OR = 2.37，95%CI：1.52至3.71，<0.001）。敏感性分析表明，即使排除患有心血管疾病或服用降脂药物的参与者，以及患有糖尿病或服用降糖药物的患者后，TyG指数与（）感染之间的关联仍然很强。
在本研究中，发现TyG指数与（）感染之间存在稳定且强烈的正相关。IR可能与（）感染显著相关。有必要进一步研究以阐明这些发现的潜在机制和临床意义。
