AstraZeneca R&D, 43183 Mölndal, Sweden.
Respir Med. 2012 Sep;106(9):1250-7. doi: 10.1016/j.rmed.2012.05.004. Epub 2012 Jun 9.
There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function.
FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The lung function measures were studied in relation to plasma levels of desmosines, C-reactive protein (CRP), plasminogen inhibitor activator (PAI-1) concentration and activity, tissue inhibitor of metalloproteinase (TIMP-1), clara cell protein 16 (CC16), surfactant protein D (SPD), matrix metalloproteinase 9 (MMP-9), hepatocyte growth factor (HGF) and interleukin (IL)-8.
After adjustments for age, sex, height, BMI and smoking, FEV(1) was significantly associated with PAI-1 activity and desmosines. RV/TLC was significantly associated with CC16, PAI-1 concentration and PAI-1 activity, and D(L)CO was significantly associated with desmosines, TIMP-1 and CRP. When the multivariate analysis was restricted to subjects with COPD (i.e., FEV(1)/FVC < 0.70), CRP and desmosines were inversely associated with lung function.
Several biomarkers were associated with lung function in this cross-sectional study. Especially CRP and desmosines could be useful markers to assess disease severity in subjects with COPD.
在 COPD 的研究和临床应用中，非常需要生物标志物。本研究探讨了十种 COPD 潜在血浆生物标志物与肺功能降低的生理测量值之间的关系。
在瑞典双胞胎登记处的 357 名受试者中评估了 FEV1、FVC、残气量/肺总量（RV/TLC）和 CO 弥散量（D（L）CO）。肺功能指标与去糠赖氨酸、C 反应蛋白（CRP）、纤溶酶原抑制剂激活物（PAI-1）浓度和活性、组织金属蛋白酶抑制剂-1（TIMP-1）、克拉拉细胞蛋白 16（CC16）、表面活性剂蛋白 D（SPD）、基质金属蛋白酶 9（MMP-9）、肝细胞生长因子（HGF）和白细胞介素（IL）-8 的血浆水平进行了研究。
在调整了年龄、性别、身高、BMI 和吸烟后，FEV1 与 PAI-1 活性和去糠赖氨酸显著相关。RV/TLC 与 CC16、PAI-1 浓度和 PAI-1 活性显著相关，D（L）CO 与去糠赖氨酸、TIMP-1 和 CRP 显著相关。当多元分析仅限于 COPD 患者（即 FEV1/FVC<0.70）时，CRP 和去糠赖氨酸与肺功能呈负相关。
在这项横断面研究中，几种生物标志物与肺功能相关。特别是 CRP 和去糠赖氨酸可能是评估 COPD 患者疾病严重程度的有用标志物。
