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药物性中性粒细胞减少症——坏死性筋膜炎的诱因?

Drug induced neutropaenia--a trigger for necrotising fasciitis?

作者信息

Foulkes Rhiannon, Hoare David, Somasekar Krishnamurthy

机构信息

General Surgery Department, Nevill Hall Hospital, Abergavenny, UK.

出版信息

BMJ Case Rep. 2011 Aug 4;2011:bcr0620114346. doi: 10.1136/bcr.06.2011.4346.

Abstract

The authors present a case of necrotising fasciitis of the peristomal area, in a patient who had undergone a previous ileostomy for ulcerative colitis. This was associated with neutropaenia, secondary to carbimazole, which had been commenced a few weeks previously for thyrotoxicosis. The authors therefore, stress the importance of monitoring patients closely for possible side effects and complications, while they are on immunosuppressive medication.

摘要

作者报告了一例造口周围坏死性筋膜炎病例,患者曾因溃疡性结肠炎接受回肠造口术。这与中性粒细胞减少有关,中性粒细胞减少继发于卡比马唑,卡比马唑几周前因甲状腺毒症开始使用。因此,作者强调在患者使用免疫抑制药物时密切监测其可能出现的副作用和并发症的重要性。

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本文引用的文献

1
Necrotizing fasciitis.坏死性筋膜炎
Intern Med. 2010;49(12):1051-7. doi: 10.2169/internalmedicine.49.2964. Epub 2010 Jun 15.
2
Periorbital necrotizing fasciitis.眶周坏死性筋膜炎
Plast Reconstr Surg. 2007 Dec;120(7):107e. doi: 10.1097/01.prs.0000287274.57709.d5.
3
Mortality in patients with necrotizing fasciitis.坏死性筋膜炎患者的死亡率。
Plast Reconstr Surg. 2007 May;119(6):1803-1807. doi: 10.1097/01.prs.0000259040.71478.27.
8
Necrotizing fasciitis.
Arch Surg. 1986 Feb;121(2):233-5. doi: 10.1001/archsurg.1986.01400020119015.

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