De Niro Jennifer Edith, Silkiss Rona Z
Ophthalmology Department, California Pacific Medical Center, San Francisco, California, United States.
BMJ Case Rep. 2011 Aug 4;2011:bcr0620114376. doi: 10.1136/bcr.06.2011.4376.
HIV-associated lipoatrophy has been closely linked to the use of the thymidine nucleoside reverse-transcriptase inhibitors stavudine and zidovudine. The lipoatrophy can have severe psychological effects and is associated with increased risk of metabolic disorders and cardiovascular disease. The authors present a case of a 45-year-old HIV-positive man who presented with severe bilateral enophthalmos (recession of the eyes) and lagophthamos (inability to fully close the eyes) from orbital fat atrophy. He had taken zidovudine for 8 years and stavudine for 13 years. Cessation of the causative drugs usually does not result in noticeable improvement of the lipoatrophy. Placement of bilateral orbital floor implants decreased our patient's orbital volume and substantially improved his eyelid function and cosmetic appearance.
与HIV相关的脂肪萎缩与使用胸苷核苷逆转录酶抑制剂司他夫定和齐多夫定密切相关。脂肪萎缩可产生严重的心理影响，并与代谢紊乱和心血管疾病风险增加有关。作者报告了一例45岁的HIV阳性男性病例，该患者因眼眶脂肪萎缩出现严重的双侧眼球内陷（眼球后缩）和兔眼症（无法完全闭眼）。他服用齐多夫定8年，司他夫定13年。停用致病药物通常不会使脂肪萎缩有明显改善。双侧眶底植入物的放置减少了我们这位患者的眼眶容积，并显著改善了他的眼睑功能和外观。
