Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, and In Vitro Drug Safety and Biotechnology, MaRS, Toronto, Ontario, Canada.
Transl Res. 2012 Jul;160(1):45-64. doi: 10.1016/j.trsl.2011.10.006. Epub 2011 Nov 23.
Strong evidence indicates that inflammatory bowel disease, including Crohn disease and ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and environmental factors play important roles. This review discusses several single-nucleotide polymorphisms with either susceptibility or protective effects on inflammatory bowel disease.
有强有力的证据表明，炎症性肠病（包括克罗恩病和溃疡性结肠炎）是一种不适当的炎症反应的结果，其中遗传和环境因素起着重要作用。本文讨论了几种单核苷酸多态性，它们对炎症性肠病具有易感性或保护作用。
