慢性乙型肝炎患者血清血小板衍生生长因子BB与肝损伤程度、纤维化及乙肝e抗原（HBeAg）状态之间的关联

Association between serum platelet-derived growth factor BB and degree of liver damage, fibrosis and hepatitis B e antigen (HBeAg) status in CHB patients.

作者信息

Diang Xiang-Chun, Ma Li-Na, Li Yu-Fang, Liu Xiao-Yan, Zhang Xu, Liu Jun-Ying, Sheng Yun-Jian, Zhang Da-Zhi, Hu Huai-Dong, Ren Hong

机构信息

Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Hepatogastroenterology. 2012 Nov-Dec;59(120):2357-60. doi: 10.5754/hge12388.

DOI:10.5754/hge12388

PMID:22688015

Abstract

BACKGROUND/AIMS: The objective of this study was to determine the association of PDGF-BB with degree of liver damage, fibrosis and HBeAg status in CHB patients.

METHODOLOGY

A total of 740 patients with previously untreated chronic hepatitis B were included in the study. We conducted the correlations analysis of se-rum PDGF-BB with the age, gender, medical history, se-rum HBV-DNA, liver function parameters and serum fibrosis markers (HA, PCIII, CIV, LN), analyzed the cor-relations of degree of liver damage with liver fibrosis markers and the serum levels of PDGF-BB and compared serum liver fibrosis markers and levels of PDGF- BB between HbeAg-negative and HbeAg-positive CHB patients.

RESULTS

Liver function parameters and se-rum liver fibrosis markers were significantly correlated with serum PDGF-BB (p<0.01). Liver fibrosis markers and serum levels of PDGF-BB in CHB were positive correlated with degree of liver damage. Serum levels of PDGF-BB in HBeAg-negative CHB was significantly higher than that in the HBeAg-positive CHB (p<0.05).

CONCLUSIONS

Serum levels of PDGF-BB can reflect degree of liver damage and degree of liver fibrosis in CHB.Serum levels of PDGF-BB in HBeAg-negative CHB were higher than the HBeAg-positive CHB.

摘要

背景/目的：本研究旨在确定血小板衍生生长因子-BB（PDGF-BB）与慢性乙型肝炎（CHB）患者肝损伤程度、纤维化程度及HBeAg状态之间的关联。

方法

本研究共纳入740例未经治疗的慢性乙型肝炎患者。我们对血清PDGF-BB与年龄、性别、病史、血清HBV-DNA、肝功能参数及血清纤维化标志物（透明质酸、Ⅲ型前胶原、Ⅳ型胶原、层粘连蛋白）进行相关性分析，分析肝损伤程度与肝纤维化标志物及血清PDGF-BB水平的相关性，并比较HBeAg阴性和HBeAg阳性CHB患者的血清肝纤维化标志物及PDGF-BB水平。