Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Can J Gastroenterol Hepatol. 2018 Jun 27;2018:9142672. doi: 10.1155/2018/9142672. eCollection 2018.
Liver pathophysiology can, directly and indirectly, impose morphological or biochemical abnormalities of the platelets. Conversely, platelets are also able to regulate the promitogenic and profibrotic signals on liver pathobiology. Platelet contribution to the liver pathophysiology is typically facilitated by the platelet-derived growth factors that are sequestered in different subsets of alpha and dense granules, and the release of these growth factors is synchronized according to the stage and type of liver disease or injury. Thus, platelets harbor clinically relevant information with potential diagnostic and prognostic implications in liver diseases. Hepatocellular carcinoma (HCC) largely influences the platelet kinetics, and a growing body of evidence has recognized its association with HCC occurrence or prognosis. This narrative review summarizes the progress made on implicating platelet as a diagnostic and prognostic tool for HCC; the review also dissects the contradictory results from earlier studies and reflects how combining platelet-based information may enable more reliable test for diagnostic and prognostic evaluation of HCC.
肝脏病理生理学可直接或间接导致血小板的形态或生化异常。相反，血小板也能够调节肝脏病理生物学中的促有丝分裂和促纤维化信号。血小板对肝脏病理生理学的贡献通常是由血小板衍生的生长因子介导的，这些生长因子被隔离在不同的α和致密颗粒亚群中，并且这些生长因子的释放根据肝病或损伤的阶段和类型而同步进行。因此，血小板具有与肝脏疾病相关的潜在诊断和预后意义的临床相关信息。肝细胞癌 (HCC) 极大地影响了血小板的动力学，越来越多的证据已经认识到它与 HCC 的发生或预后有关。本综述总结了将血小板作为 HCC 诊断和预后工具的研究进展；还分析了早期研究中相互矛盾的结果，并反映了如何结合基于血小板的信息可以为 HCC 的诊断和预后评估提供更可靠的检测方法。
