Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences, Institute for Technology & Research Innovation, Deakin University, Geelong, Victoria, Australia.
Med Res Rev. 2013 Jul;33(4):765-89. doi: 10.1002/med.21264. Epub 2012 Jun 11.
Survivin is an inhibitor of apoptosis protein (IAP) family member preferentially expressed in a myriad of clinical cancers. The complex functional mechanism and regulatory roles of survivin in cell division and cell death has hindered current therapeutic regimes from decoding its diagnostic, prognostic, and therapeutic significance in the area of translational oncology. Pharmacological modulation of survivin was tagged with its evolving functional complexity associated with various cell-signaling cascades including PI3K/AKT, mammalian target of rapamycin (mTOR), extracellular signal-regulated kinases (ERK), mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription (STAT), hypoxia-inducible factor-1α (HIF-1α), heat-shock protein 90 (HSP90), p53, B-cell lymphoma 2 (Bcl2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) etc. The present review provides a multifaceted role of survivin and its mechanistic action in an array of clinical cancers. Furthermore, the utilization of novel nanotechnology-based drug delivery systems for target-specific hurling of tumors enabling contemporaneous detection, treatment, and therapeutic imaging in cancer therapy are discussed.
生存素是凋亡抑制蛋白（IAP）家族的成员，在许多临床癌症中特异性表达。生存素在细胞分裂和细胞死亡中的复杂功能机制和调节作用，阻碍了当前的治疗方案来解码其在转化肿瘤学领域的诊断、预后和治疗意义。生存素的药理学调节与其相关的各种细胞信号级联的不断演变的功能复杂性相关，包括 PI3K/AKT、雷帕霉素靶蛋白（mTOR）、细胞外信号调节激酶（ERK）、丝裂原激活蛋白激酶（MAPK）、信号转导和转录激活因子（STAT）、缺氧诱导因子-1α（HIF-1α）、热休克蛋白 90（HSP90）、p53、B 细胞淋巴瘤 2（Bcl2）、表皮生长因子受体（EGFR）、血管内皮生长因子（VEGF）等。本综述提供了生存素及其在多种临床癌症中的机制作用的多方面作用。此外，还讨论了利用新型基于纳米技术的药物输送系统对肿瘤进行靶向投掷，以便在癌症治疗中进行同时检测、治疗和治疗成像。
