T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication.
作者信息
Liu L F, Liu C C, Alberts B M
出版信息
Nature. 1979 Oct 11;281(5731):456-61. doi: 10.1038/281456a0.
DOI:10.1038/281456a0
PMID:226889
Abstract
A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.
摘要
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