Department of Chemistry, National Central University, Chung-Li 32054, Taiwan.
Chem Asian J. 2012 Sep;7(9):2111-7. doi: 10.1002/asia.201200244. Epub 2012 Jun 11.
Functionalization of periodic mesoporous organosilicas (PMOs) with high loadings of pendant organic groups to form bifunctional PMOs with ordered mesostructures remains a challenging objective. Herein, we report that well-ordered ethane-bridged PMOs functionalized with exceptionally high loadings of pendant carboxylic acid groups (up to 80 mol % based on silica) were synthesized by the co-condensation of 1,4-bis(trimethoxysilyl)ethane (BTME) and carboxyethylsilanetriol sodium salt (CES) with Pluronic P123 as the template and KCl as an additive under acidic conditions. The bifunctional materials were characterized by using a variety of techniques, including powder X-ray diffraction, nitrogen-adsorption/desorption, TEM, and solid-state (13)C and (29)Si NMR spectroscopy. Zeta-potential measurements showed that the surface negative charges increased with increasing the CES content. This property makes them potential candidates for applications in drug adsorption. The excellent adsorption capacity of these bifunctional PMOs towards an anticancer drug (doxorubicin) was also demonstrated.
将周期性介孔有机硅（PMO）官能化，使其带有高负载的悬垂有机基团，从而形成具有有序介孔结构的双功能 PMO，这仍然是一个具有挑战性的目标。在此，我们报告了通过 1,4-双（三甲氧基硅基）乙烷（BTME）和羧乙基硅三醇钠盐（CES）与 Pluronic P123 共缩聚，并在酸性条件下添加 KCl，合成了具有极高负载量的悬垂羧酸基团（基于二氧化硅最高可达 80mol%）的有序乙烷桥联 PMO。采用多种技术对双功能材料进行了表征，包括粉末 X 射线衍射、氮吸附/解吸、TEM 以及固态（13）C 和（29）Si NMR 光谱。Zeta 电位测量表明，随着 CES 含量的增加，表面负电荷增加。这种特性使它们成为药物吸附应用的潜在候选材料。这些双功能 PMO 对一种抗癌药物（阿霉素）的优异吸附能力也得到了证明。
