Rodríguez-Commes J L, Tabernero J M, Martin-Vasallo P, De Castro S, Battaner E
Nephron. 1979;24(1):21-4. doi: 10.1159/000181677.
This paper starts a series on red blood cell (RBC) metabolism in patients with chronic renal failure (CRF). The glycolytic enzyme levels and in vitro half-lives of these patients' RBCs were determined. A number of enzymes (hexokinase, glucose-6-phosphate isomerase, fructose-6-phosphate kinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase) showed higher activities than in normal control RBCs. Other enzyme activities were normal. These results were discussed and several possible mechanisms considered. We favour the point of view of a shortened life span of the RBCs in CRF, making the most unstable enzymes of the glycolytic sequence appear increase as compared with normal controls.
本文开启了关于慢性肾衰竭（CRF）患者红细胞（RBC）代谢的系列研究。测定了这些患者红细胞的糖酵解酶水平及体外半衰期。一些酶（己糖激酶、葡萄糖-6-磷酸异构酶、果糖-6-磷酸激酶、醛缩酶、甘油醛-3-磷酸脱氢酶和乳酸脱氢酶）的活性高于正常对照红细胞。其他酶的活性正常。对这些结果进行了讨论，并考虑了几种可能的机制。我们倾向于认为CRF患者红细胞寿命缩短的观点，这使得糖酵解序列中最不稳定的酶与正常对照相比显得增加。
