Thapa Lekhjung, Paudel Raju, Chhetri Pramod, Rana P V S
Department of Neurology, College of Medical Sciences-Teaching Hospital, Bharatpur, Nepal.
BMJ Case Rep. 2011 Jul 28;2011:bcr0620114366. doi: 10.1136/bcr.06.2011.4366.
A 27-year-old man presented with diplopia without features of raised intracranial pressure. He had left sixth cranial nerve (CN) palsy. Initial investigations in the form of blood tests, cerebrospinal fluid (CSF) opening pressure including CSF analysis and CT head were normal. He represented with paraparesis after 3 weeks. Examination revealed sixth CN palsy (eye twist) and new left-sided twelfth CN palsy (tongue twist), and hence Godtfredsen syndrome was diagnosed. MRI showed vertebral and clivus metastases. He showed partial response to high dose steroid. The statement 'sixth CN palsy may be a false localising sign' in neurology, should be followed by '....it can also be a true initial sign of clivus mass.'
一名27岁男性出现复视而无颅内压升高的表现。他有左侧第六颅神经(CN)麻痹。最初的检查包括血液检查、脑脊液(CSF)开放压(包括CSF分析)和头颅CT均正常。3周后他再次就诊,出现双下肢轻瘫。检查发现第六颅神经麻痹(眼球扭转)和新出现的左侧第十二颅神经麻痹(舌扭转),因此诊断为戈特弗雷森综合征。MRI显示椎体和斜坡转移瘤。他对高剂量类固醇治疗有部分反应。神经病学中“第六颅神经麻痹可能是一个假定位体征”这句话之后应接着说“……它也可能是斜坡肿物的真正初始体征”。