Kumar Sumir, Garg Ravinder, Aggarwal Simmi, Kaur Jaskanwal
Department of Dermatology, GGS Medical College and Hospital, Faridkot, Punjab, India.
J Nat Sci Biol Med. 2012 Jan;3(1):87-9. doi: 10.4103/0976-9668.95980.
Isolated cutaneous sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. Cutaneous lesions have been classified into specific and nonspecific depending on the presence of noncaseating granulomas on histopathologic studies. Macrophages most likely initiate the response of sarcoidosis by presenting unidentified antigens to CD4+ lymphocytes. A persistent poorly degradable antigen-driven CMI response leads to cytokine cascade, granulomaformation, and fibrosis. In the present study, we report a case of isolated cutaneous sarcoidosis, localized to the face, in an adolescent girl without systemic manifestations which is a rare entity.
孤立性皮肤结节病是一种病因不明的罕见多系统肉芽肿性疾病。根据组织病理学研究中是否存在非干酪样肉芽肿，皮肤病变可分为特异性和非特异性。巨噬细胞很可能通过将未识别的抗原呈递给CD4+淋巴细胞来启动结节病反应。持续的、难以降解的抗原驱动的细胞介导免疫反应导致细胞因子级联反应、肉芽肿形成和纤维化。在本研究中，我们报告了一例局限于面部的孤立性皮肤结节病病例，该病例发生在一名无全身表现的青春期女孩身上，这是一种罕见的情况。
