Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
J Korean Med Sci. 2012 Jun;27(6):668-73. doi: 10.3346/jkms.2012.27.6.668. Epub 2012 May 26.
This study was performed to assess the usefulness of magnetoencephalography (MEG) as a presurgical evaluation modality in Korean pediatric patients with lesional localization-related epilepsy. The medical records and MEG findings of 13 pediatric patients (6 boys and 7 girls) with localization-related epilepsy, who underwent epilepsy surgery at Seoul National University Children's Hospital, were retrospectively reviewed. The hemispheric concordance rate was 100% (13/13 patients). The lobar or regional concordance rate was 77% (10/13 patients). In most cases, the MEG spike sources were clustered in the proximity of the lesion, either at one side of the margin (nine patients) or around the lesion (one patient); clustered spike sources were distant from the lesion in one patient. Among the patients with clustered spike sources near the lesion, further extensions (three patients) and distal scatters (three patients) were also observed. MEG spike sources were well lateralized and localized even in two patients without focal epileptiform discharges in the interictal scalp electroencephalography. Ten patients (77%) achieved Engel class I postsurgical seizure outcome. It is suggested that MEG is a safe and useful presurgical evaluation modality in pediatric patients with lesion localization-related epilepsy.
本研究旨在评估脑磁图（MEG）作为韩国有病变定位相关癫痫的儿科患者术前评估手段的有效性。回顾性分析了在首尔国立大学儿童医院接受癫痫手术的 13 例病变定位相关癫痫的儿科患者（男 6 例，女 7 例）的病历和 MEG 检查结果。半球一致性率为 100%（13/13 例）。叶或区域一致性率为 77%（10/13 例）。在大多数情况下，MEG 棘波源集中在病变附近，要么在边缘一侧（9 例），要么在病变周围（1 例）；1 例患者棘波源远离病变。在病变附近有簇状棘波源的患者中，还观察到进一步的扩展（3 例）和远端分散（3 例）。即使在 2 例发作间期头皮脑电图无局灶性癫痫样放电的患者中，MEG 棘波源也能很好地定位。10 例（77%）患者术后癫痫发作达到 Engel Ⅰ级。提示 MEG 是病变定位相关癫痫的儿科患者安全有效的术前评估手段。
