School of Biomedicine, Far Eastern Federal University, 8, Sukhanova str., Vladivostok, 690091, Russia.
A.V. Zhirmunski Institute of Marine Biology, Far Eastern Branch of Russian Academy of Sciences, 17, Palchevskgo str., Vladivostok, 690059, Russia.
Mar Drugs. 2012 Apr;10(4):834-848. doi: 10.3390/md10040834. Epub 2012 Apr 5.
Cerium binding activity of three different water soluble pectin compounds of different origin was studied in a batch sorption system. The Langmuir, Freundlich and BET sorption models were adopted to describe the binding reactions between metal ions and pectin molecules. The Langmuir model provided the best fit. Within the pH range from 4.0 to 6.0, the largest amount of the cerium ions was bound by pectin isolated from the seagrass Phylospadix iwatensis in comparison to pectin extracted from the seagrass Zostera marina and pectin obtained from citrus peel (commercial grade). The Langmuir constants were also highest for the pectin samples isolated from the seagrass P. iwatensis. The results obtained from this study suggest that pectin is a prospective source for the development of radioisotope-removing pharmaceuticals.
在批处理吸附系统中研究了三种不同来源的水溶性果胶化合物的铈结合活性。采用 Langmuir、Freundlich 和 BET 吸附模型来描述金属离子与果胶分子之间的结合反应。Langmuir 模型提供了最佳拟合。在 pH 值为 4.0 到 6.0 的范围内，与从海草 Zostera marina 和柑橘皮（商业级）中提取的果胶相比，从海草 Phyllospadix iwatensis 中分离得到的果胶结合了最多的铈离子。对于从 P. iwatensis 海草中分离得到的果胶样品，Langmuir 常数也最高。本研究结果表明，果胶是开发放射性同位素去除药物的有前途的来源。
