• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

海洋来源的博斯他汀衍生物的合成及其对肿瘤细胞的构效关系研究。

Studies on the synthesis of derivatives of marine-derived bostrycin and their structure-activity relationship against tumor cells.

机构信息

School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China.

Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China.

出版信息

Mar Drugs. 2012 Apr;10(4):932-952. doi: 10.3390/md10040932. Epub 2012 Apr 24.

DOI:10.3390/md10040932
PMID:22690152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3366684/
Abstract

A series of new derivatives (5-29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data.

摘要

合成了一系列新型海洋来源的博斯他汀（1）衍生物（5-29）。采用 MTT 法测定了所有化合物对 MCF-7、MDA-MB-435、A549、HepG2、HCT-116 和 MCF-10A 细胞的体外细胞毒性。总共有 7、8、22、23、25、28 和 29 个化合物对所选癌细胞系的活性与阳性对照表阿霉素相当。然而，这些化合物对 MCF-10A 细胞也表现出细胞毒性。还根据获得的实验数据讨论了博斯他汀衍生物的构效关系（SAR）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/60389830eb0f/marinedrugs-10-00932-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/a66ded491857/marinedrugs-10-00932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/ad54ad893265/marinedrugs-10-00932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/2a308a8defaa/marinedrugs-10-00932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/3d9a3eeffc59/marinedrugs-10-00932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/33e938395e99/marinedrugs-10-00932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/60389830eb0f/marinedrugs-10-00932-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/a66ded491857/marinedrugs-10-00932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/ad54ad893265/marinedrugs-10-00932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/2a308a8defaa/marinedrugs-10-00932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/3d9a3eeffc59/marinedrugs-10-00932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/33e938395e99/marinedrugs-10-00932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a8/3366684/60389830eb0f/marinedrugs-10-00932-g006.jpg

相似文献

1
Studies on the synthesis of derivatives of marine-derived bostrycin and their structure-activity relationship against tumor cells.海洋来源的博斯他汀衍生物的合成及其对肿瘤细胞的构效关系研究。
Mar Drugs. 2012 Apr;10(4):932-952. doi: 10.3390/md10040932. Epub 2012 Apr 24.
2
Synthesis and antitumor activities of derivatives of the marine mangrove fungal metabolite deoxybostrycin.海洋红树真菌代谢产物去甲博斯他汀衍生物的合成与抗肿瘤活性。
Mar Drugs. 2012 Nov 30;10(12):2715-28. doi: 10.3390/md10122715.
3
Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach.通过生物电子等排体方法设计与合成新型羟基蒽醌氮芥衍生物作为潜在抗癌剂
Eur J Med Chem. 2015 Sep 18;102:303-9. doi: 10.1016/j.ejmech.2015.08.006. Epub 2015 Aug 6.
4
Synthesis of novel bis-anthraquinone derivatives and their biological evaluation as antitumor agents.新型双蒽醌衍生物的合成及其作为抗肿瘤剂的生物评价。
Arch Pharm Res. 2013 May;36(5):573-8. doi: 10.1007/s12272-013-0074-x. Epub 2013 Mar 8.
5
Thieno[2,3-d]pyrimidin-4(3H)-one Derivatives of Benzimidazole as Potential Anti- Breast Cancer (MDA-MB-231, MCF-7) Agents.苯并咪唑噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物作为潜在的抗乳腺癌（MDA-MB-231，MCF-7）药物。
Anticancer Agents Med Chem. 2021;21(11):1441-1450. doi: 10.2174/1871520620666200721131431.
6
Synthesis and antitumor activity of natural compound aloe emodin derivatives.天然化合物芦荟大黄素衍生物的合成及其抗肿瘤活性
Chem Biol Drug Des. 2015 May;85(5):638-44. doi: 10.1111/cbdd.12448. Epub 2014 Nov 5.
7
Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents.从瑞香素出发的基于天然产物的设计、合成和生物评价新型抗肿瘤剂蒽[2,1-d]噻唑-6,11-二酮衍生物。
Eur J Med Chem. 2014 Sep 12;84:505-15. doi: 10.1016/j.ejmech.2014.07.047. Epub 2014 Jul 15.
8
Design, synthesis and cytotoxic effect of hydroxy- and 3-alkylaminopropoxy-9,10-anthraquinone derivatives.羟基和3-烷基氨基丙氧基-9,10-蒽醌衍生物的设计、合成及细胞毒性作用
Bioorg Med Chem. 2005 May 16;13(10):3439-45. doi: 10.1016/j.bmc.2005.03.001.
9
Synthesis and biological activity of anthrapyrazoles derivatives as potential antitumor agents.作为潜在抗肿瘤剂的蒽并吡唑类衍生物的合成及生物活性
Med Chem. 2014;10(8):772-7. doi: 10.2174/1573406410666140428152227.
10
Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity.具有细胞毒性活性的新型1,5 - 二氮杂蒽醌的合成与生物学评价
Bioorg Med Chem. 2004 Dec 15;12(24):6505-15. doi: 10.1016/j.bmc.2004.09.021.

引用本文的文献

1
Non-coding RNA-related antitumor mechanisms of marine-derived agents.海洋来源药物的非编码RNA相关抗肿瘤机制
Front Pharmacol. 2022 Dec 1;13:1053556. doi: 10.3389/fphar.2022.1053556. eCollection 2022.
2
Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K/AKT/mTOR Signaling Pathway.黑麦酮 B，一种潜在的抗宫颈癌药物，通过 PI3K/AKT/mTOR 信号通路诱导人宫颈癌 Ca Ski 细胞凋亡和保护性自噬。
Molecules. 2022 Apr 9;27(8):2431. doi: 10.3390/molecules27082431.
3
Bostrycin inhibits growth of tongue squamous cell carcinoma cells by inducing mitochondrial apoptosis.

本文引用的文献

1
Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea.从南海红树林内生真菌链格孢属 ZJ9-6B 中分离得到的三种双蒽醌衍生物。
Mar Drugs. 2011;9(5):832-843. doi: 10.3390/md9050832. Epub 2011 May 12.
2
Two new derivatives of griseofulvin from the mangrove endophytic fungus Nigrospora sp. (strain No. 1403) from Kandelia candel (L.) Druce.从红树林内生真菌（株号 1403）Nigrospora sp. 中分离得到的灰黄霉素的两个新衍生物。该真菌来源于海檬果（Kandelia candel（L.）Druce）。
Planta Med. 2011 Oct;77(15):1735-8. doi: 10.1055/s-0030-1271040. Epub 2011 Apr 21.
3
Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway.
博斯特里辛通过诱导线粒体凋亡来抑制舌鳞状细胞癌细胞的生长。
Transl Cancer Res. 2020 Jun;9(6):3926-3936. doi: 10.21037/tcr-19-2076.
4
Bioactive compounds from an endophytic fungi Nigrospora aurantiaca.来自内生真菌aurantica黑孢霉的生物活性化合物。 （你提供的原文中“Nigrospora aurantiaca”可能有误，正确的应该是“Nigrospora aurantia” ，这里按你提供的翻译为“aurantica黑孢霉” ）
Bot Stud. 2021 Oct 26;62(1):18. doi: 10.1186/s40529-021-00324-7.
5
Bioactivities and Structure-Activity Relationships of Natural Tetrahydroanthraquinone Compounds: A Review.天然四氢蒽醌化合物的生物活性及构效关系综述
Front Pharmacol. 2020 May 27;11:799. doi: 10.3389/fphar.2020.00799. eCollection 2020.
6
Cytotoxic and Antibacterial Compounds from the Coral-Derived Fungus Aspergillus tritici SP2-8-1.从珊瑚来源真菌 Aspergillus tritici SP2-8-1 中分离得到的细胞毒性和抗菌化合物。
Mar Drugs. 2017 Nov 7;15(11):348. doi: 10.3390/md15110348.
7
Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?某些海洋来源的真菌代谢产物能成为真正的抗癌药物吗？
Mar Drugs. 2015 Jun 19;13(6):3950-91. doi: 10.3390/md13063950.
8
A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012.2012年报道的具有抗癌活性的海洋天然化合物及其衍生物调查。
Molecules. 2015 Apr 20;20(4):7097-142. doi: 10.3390/molecules20047097.
9
The anthraquinone derivatives from the fungus Alternaria sp. XZSBG-1 from the saline lake in Bange, Tibet, China.来自中国西藏班戈盐湖的链格孢属真菌XZSBG-1的蒽醌衍生物。
Molecules. 2014 Oct 14;19(10):16529-42. doi: 10.3390/molecules191016529.
10
New dimeric members of the phomoxanthone family: phomolactonexanthones A, B and deacetylphomoxanthone C isolated from the fungus Phomopsis sp.新型二聚体角鲨烷家族成员：从真菌 Phomopsis sp. 中分离得到的 phomolactonexanthones A、B 和 deacetylphomoxanthone C。
Mar Drugs. 2013 Dec 11;11(12):4961-72. doi: 10.3390/md11124961.
博斯替星通过下调 PI3K/Akt 通路抑制人肺癌 A549 细胞的增殖。
J Exp Clin Cancer Res. 2011 Feb 8;30(1):17. doi: 10.1186/1756-9966-30-17.
4
The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae.蒽二酮化合物博斯他汀诱导酵母酿酒酵母中线粒体介导的细胞凋亡。
FEMS Yeast Res. 2010 May;10(3):297-308. doi: 10.1111/j.1567-1364.2010.00615.x. Epub 2010 Mar 3.
5
SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway.SZ-685C，一种海洋蒽醌类化合物，通过抑制 Akt/FOXO 通路，是一种强效的凋亡诱导剂，具有抗癌活性。
Br J Pharmacol. 2010 Feb 1;159(3):689-97. doi: 10.1111/j.1476-5381.2009.00577.x. Epub 2010 Jan 28.
6
Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.新型含氮和硫杂原子的1,4-萘醌作为高效抗真菌和抗菌剂的设计、合成及生物学评价
Eur J Med Chem. 2009 Aug;44(8):3130-7. doi: 10.1016/j.ejmech.2009.03.006. Epub 2009 Mar 21.
7
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.2,3-二取代-1,4-萘醌、12H-苯并[b]吩噻嗪-6,11-二酮及相关化合物：作为潜在抗增殖和抗真菌剂的合成与生物学评价
Eur J Med Chem. 2009 Mar;44(3):1086-92. doi: 10.1016/j.ejmech.2008.06.025. Epub 2008 Jul 2.
8
(1)H and (13)C NMR assignments for five anthraquinones from the mangrove endophytic fungus Halorosellinia sp. (No. 1403).来自红树林内生真菌嗜盐座壳孢菌（编号1403）的五种蒽醌的（1）H和（13）C核磁共振谱归属
Magn Reson Chem. 2007 Nov;45(11):1006-9. doi: 10.1002/mrc.2078.
9
Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents.1,2,3-三取代-1,4-二氢苯并[g]喹喔啉-5,10-二酮及相关化合物作为抗真菌和抗菌剂的设计、合成与生物学评价
Bioorg Med Chem. 2006 Sep 1;14(17):6120-6. doi: 10.1016/j.bmc.2006.04.029. Epub 2006 Jun 27.
10
Auxarthrol A and auxarthrol B: two new tetrahydoanthraquinones from Auxarthron umbrinum.奥克节肢菌素A和奥克节肢菌素B：来自暗褐节肢菌的两种新四氢蒽醌。
J Ind Microbiol Biotechnol. 2004 Jan;31(1):11-5. doi: 10.1007/s10295-003-0106-5. Epub 2004 Jan 29.