Esmat Serag, Omran Dalia, Sleem Gihan A, Rashed Laila
Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hepat Mon. 2012 Apr;12(4):259-64. doi: 10.5812/hepatmon.704. Epub 2012 Apr 30.
Chronic hepatitis C virus (HCV) infection is a major worldwide public health problem. Egypt has the highest prevalence of adult HCV infection in the world, averaging 15%-25% in rural communities. Mannan-binding lectin (MBL) is a liver-derived pluripotent serum lectin that plays a role in the innate immune system of the host. It is an acute-phase protein that is involved in the activation of the classical complement pathway. MBL may play a defensive role in HCV infection.
To investigate the relationship between MBL concentration and HCV infection in Egyptian patients suffering chronic hepatitis C.
Serum samples obtained from 35 Egyptian hepatitis C patients and 30 normal controls were assayed for MBL. MBL concentrations were correlated to disease characteristics and treatment response.
Serum MBL was significantly higher in HCV patients than in controls, but no relationship was found between MBL concentration and disease progression in terms of hepatic fibrosis and inflammation. Responders to interferon (INF)-based therapy had significantly higher serum MBL than non-responders.
We found no association between serum MBL concentration and progression of HCV related liver disease. Responders to INF-based therapy had significantly higher serum MBL than non-responders.
慢性丙型肝炎病毒（HCV）感染是全球主要的公共卫生问题。埃及是世界上成人HCV感染率最高的国家，农村社区平均感染率为15%-25%。甘露糖结合凝集素（MBL）是一种肝脏来源的多能血清凝集素，在宿主的固有免疫系统中发挥作用。它是一种急性期蛋白，参与经典补体途径的激活。MBL可能在HCV感染中发挥防御作用。
研究埃及慢性丙型肝炎患者MBL浓度与HCV感染之间的关系。
对35例埃及丙型肝炎患者和30例正常对照者的血清样本进行MBL检测。MBL浓度与疾病特征和治疗反应相关。
HCV患者血清MBL显著高于对照组，但在肝纤维化和炎症方面，MBL浓度与疾病进展之间未发现相关性。基于干扰素（INF）治疗的应答者血清MBL显著高于无应答者。
我们发现血清MBL浓度与HCV相关肝病的进展之间无关联。基于INF治疗的应答者血清MBL显著高于无应答者。
