Han Y L, Zhu S J, Lu Y M
Second Affiliated Hospital, Third Military Medical College, Chongqing.
Zhonghua Nei Ke Za Zhi. 1990 Jun;29(6):324-7, 381.
Clinical and hemodynamic studies were carried out in 20 patients suffering from refractory congestive heart failure with invasive technique and non-invasive methods such as tolerance exercise test, 24-hour Holter monitoring, etc. Digitalis was then withdrawn and China-made amrinone (AMR) was administered orally for 15 days. All the indices mentioned above were repeated and each patient served as his own control. The results indicate that AMR can improve hemodynamic parameters as well as exercise tolerance. Holter monitoring revealed no significant increase in arrythmogenic potentiality. The total clinical effective rate was 95%. No severe side effects were found except thrombocytopenia observed in 20% of the patients. It is suggested that China-made AMR is effective in treating refractory congestive heart failure.
对20例难治性充血性心力衰竭患者采用有创技术及无创方法如运动耐量试验、24小时动态心电图监测等进行了临床和血流动力学研究。然后停用洋地黄，口服国产氨力农（AMR）15天。重复上述所有指标，每位患者自身作为对照。结果表明，AMR可改善血流动力学参数及运动耐量。动态心电图监测显示致心律失常可能性无显著增加。总临床有效率为95%。除20%的患者观察到血小板减少外，未发现严重副作用。提示国产AMR治疗难治性充血性心力衰竭有效。
