Erskine M S, Geller E, Yuwiler A
Neuroendocrinology. 1979;29(3):191-9. doi: 10.1159/000122922.
Administration of corticosteroids to rat pups within the first several days of life results in retardation of several behavioral, neurophysiological, and biochemical developmental patterns. At 25 days of age, animals treated neonatally with 1.0, 0.5, or 0.1 mg hydrocortisone acetate showed dose-dependent decreases in plasma ACTH following 2.5 min continuous exposure to ether. On day 20, plasma corticosterone values did not differ between these groups 15 min after ether stress, but lower values were seen 60 min after ether in animals treated at birth with 0.5 mg hydrocortisone. At 45--48 days of age, hydrocortisone-treated animals exposed to one of 2 different stressors showed decreased plasma corticosterone response to stress; females had lower corticosterone levels following both stressors, while males showed suppressed corticosterone levels following exposure to the mild (novelty) but not to the intense (ether) stress. These data demonstrate that neonatal exposure to hydrocortisone results in decreased CNS-pituitary responsivity to stress at 20--25 days of age, and that the adrenocortical response to stress in impaired at 45--48 days of age.
在幼鼠出生后的头几天内给予皮质类固醇会导致其一些行为、神经生理和生化发育模式出现迟缓。在25日龄时，出生时接受1.0、0.5或0.1毫克醋酸氢化可的松治疗的动物，在持续暴露于乙醚2.5分钟后，血浆促肾上腺皮质激素（ACTH）呈剂量依赖性下降。在第20天，这些组在乙醚应激15分钟后血浆皮质酮值没有差异，但出生时接受0.5毫克氢化可的松治疗的动物在乙醚应激60分钟后血浆皮质酮值较低。在45 - 48日龄时，接受氢化可的松治疗的动物暴露于两种不同应激源之一后，对压力的血浆皮质酮反应降低；两种应激源后雌性动物的皮质酮水平较低，而雄性动物在暴露于轻度（新奇）应激源而非强烈（乙醚）应激源后皮质酮水平受到抑制。这些数据表明，新生期暴露于氢化可的松会导致20 - 25日龄时中枢神经系统 - 垂体对应激的反应性降低，并且在45 - 48日龄时肾上腺皮质对应激的反应受损。
