Kimata Takahisa, Kaneko Kazunari, Takahashi Masaya, Yamanouchi Sohsaku, Tsuji Shoji, Kino Minoru
Department of Pediatrics, Kansai Medical University.
Pediatr Rep. 2012 Jan 2;4(1):e14. doi: 10.4081/pr.2012.e14. Epub 2012 Mar 26.
It is known that ceftriaxone administration is associated with biliary pseudolithiasis, although the development of urolithiasis has been rarely reported. We encountered a young male with bacterial meningitis complicated by urinary precipitates composed of ceftriaxone-calcium salt which is confirmed by high-performance liquid chromatography. This patient suggested that ceftriaxone significantly increased urinary excretion of calcium, which may be linked to ceftriaxone-related urolithiasis or sludge. It is therefore worthwhile to monitor the levels of urinary calcium to creatinine ratio in patients on ceftriaxone, as they may be at greater risk for developing large stones and renal damage.
已知头孢曲松的使用与胆汁假性结石有关，尽管很少有关于尿路结石形成的报道。我们遇到一名年轻男性，患有细菌性脑膜炎，并伴有由头孢曲松钙盐组成的尿沉淀物，这通过高效液相色谱法得到证实。该患者提示头孢曲松显著增加了尿钙排泄，这可能与头孢曲松相关的尿路结石或沉淀物有关。因此，对于使用头孢曲松的患者，监测尿钙与肌酐比值水平是值得的，因为他们可能有形成大结石和肾损伤的更高风险。
