Walter Clare, Ball David, Duffy Mary, Mellor James D
Pharmacy Department, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, VIC 3002, Australia.
Case Rep Oncol Med. 2012;2012:261787. doi: 10.1155/2012/261787. Epub 2012 May 29.
A 77-year-old female with recurrent non-small-cell lung cancer presented to a hospital outpatient clinic with tremor, weakness, inability to coordinate motor movements, and confusion. It was suspected that the symptoms were due to possible central nervous system metastases; however, a CT scan of her head was unremarkable. The lung clinic liaison pharmacist took a medication history from the patient, complimented by extra information from the patient's community pharmacy. The pharmacist suspected the rare side effect of serotonin syndrome was responsible for the patient's presenting symptoms caused by the combination of oxycodone and citalopram. The patient's symptoms resolved soon after oxycodone was changed to morphine.
一名77岁复发性非小细胞肺癌女性患者前往医院门诊，出现震颤、虚弱、无法协调运动以及意识模糊症状。怀疑这些症状可能是由于中枢神经系统转移所致；然而，其头部CT扫描结果并无异常。肺部门诊联络药师从患者处获取了用药史，并从患者社区药房获得了额外信息作为补充。药师怀疑羟考酮和西酞普兰联用导致了罕见的血清素综合征副作用，从而引发了患者目前的症状。将羟考酮换成吗啡后，患者症状很快得到缓解。
